Publications by authors named "Davorka Repac-Antic"
, responsible for a majority of human and nosocomial enterococcal infections, is intrinsically resistant to aminoglycoside antibiotics (such as gentamicin, GEN), which must be used in a combined therapy to be effective. Nitroxoline (NTX) is an old antibiotic, underused for decades, but rediscovered now in an era of growing antibiotic resistance. In this in vitro study, the types of interactions between NTX and GEN on 29 strains were analyzed with an aim to find synergistic antimicrobial and antiadhesion combinations.
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- * This study analyzed 247 patients with inconclusive PCR tests and found that 29.4% of them tested positive upon retesting within a week.
- * The findings emphasize the importance of retesting patients with borderline results to prevent the spread of the virus within healthcare settings.
In the era of escalating antimicrobial resistance, the need for antibacterial drugs with novel or improved modes of action (MOAs) is a health concern of utmost importance. Adding or improving the chelating abilities of existing drugs or finding new, nature-inspired chelating agents seems to be one of the major ways to ensure progress. This review article provides insight into the modes of action of antibacterial agents, class by class, through the perspective of chelation.
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- Carbapenem-resistant bacteria are becoming a major concern in healthcare, and this study focuses on an outbreak of ertapenem-resistant strains in a Croatian hospital between 2012 and 2014.
- The research investigated the genetic relationships among these strains and the mechanisms causing their resistance to antibiotics, finding a link to the expression of certain porin channels.
- The results highlighted that most of the resistant isolates were genetically similar and suggested that these mutants could lead to further outbreaks if not managed carefully.