A State-of-the-Art Systemic Review on Selenium Nanoparticles: Mechanisms and Factors Influencing Biogenesis and Its Potential Applications.

Selenium is a trace element required for the active function of numerous enzymes and various physiological processes. In recent years, selenium nanoparticles draw the attention of scientists and researchers because of its multifaceted uses. The process involved in chemically synthesized SeNPs has been found to be hazardous in nature, which has paved the way for safe and ecofriendly SeNPs to be developed in order to achieve sustainability.

Bioisosteric replacements of tyrosine kinases inhibitors to make potent and safe chemotherapy against malignant cells.

The liver function test is an imperative element in chemotherapy management due to the idiosyncratic reaction of chemotherapy drugs. This study primly aimed to replace the toxic fragments of known protein tyrosine kinases inhibitors (PTKi) to develop safe and effective chemotherapy. All the current PTKi's were docked with the tyrosine kinases and metabolic enzymes to study the affinities on the target.

Bioinformatics strategies for studying the molecular mechanisms of fungal extracellular vesicles with a focus on infection and immune responses.

Fungal extracellular vesicles (EVs) are released during pathogenesis and are found to be an opportunistic infection in most cases. EVs are immunocompetent with their host and have paved the way for new biomedical approaches to drug delivery and the treatment of complex diseases including cancer. With computing and processing advancements, the rise of bioinformatics tools for the evaluation of various parameters involved in fungal EVs has blossomed.

Emerging Strategies in Stimuli-Responsive Nanocarriers as the Drug Delivery System for Enhanced Cancer Therapy.

The conventional Drug Delivery System (DDS) has limitations such as leakage of the drug, toxicity to normal cells and loss of drug efficiency, while the stimuli-responsive DDS is non-toxic to cells, avoiding the leakage and degradation of the drug because of its targeted drug delivery to the pathological site. Thus nanomaterial chemistry enables - the development of smart stimuli-responsive DDS over the conventional DDS. Stimuliresponsive DDS ensures spatial or temporal, on-demand drug delivery to the targeted cancer cells.

Synthesis of Biocompatible Cellulose-Coated Nanoceria with pH-Dependent Antioxidant Property.

Recent developments in nanomedicine have validated nanoceria as an antioxidant of therapeutic potential. However, its clinical application is far too limited in view of its poor stability and the use of hazardous solvents during its synthesis. There is a pertinent need for development of improved strategies for nanoceria to work better, especially by complexation with a matrix to improve upon its antioxidant property without toxicity.

Antimicrobial, Anticancer Drug Carrying Properties of Biopolymers-based Nanocomposites- A Mini Review.

Biopolymers are ubiquitous in biomedical and healthcare application. Its nanocomposites have gained more attention as antimicrobials, a drug carrier, sensors, disease diagnosis, tissue engineering, wound healing, and cancer therapy. These biopolymer composites are efficient in holding, protecting and releasing bioactive drugs such as pharmaceutics, nutraceuticals, enzymes, and probiotics.