Targeting cis-p-tau and neuro-related gene expression in traumatic brain injury: therapeutic insights from TC-DAPK6 treatment in mice.

Background: Traumatic brain injury (TBI) is a significant global health concern and is characterized by brain dysfunction resulting from external physical forces, leading to brain pathology and neuropsychiatric disorders such as anxiety. This study investigates the effects of TC-DAPK6 on tau hyper-phosphorylation, gene expression, anxiety, and behavior impairment in the TBI mice model.

Methods And Results: A weight drop model induced the TBI and the anxiety levels were evaluated using an elevated plus maze (EPM) test.

Silk fibroin/vitreous humor hydrogel scaffold modified by a carbodiimide crosslinker for wound healing.

Natural-derived biomaterials can be used as substrates for the growth, proliferation, and differentiation of cells. In this study, bovine vitreous humor as a biological material was cross-linked to silk fibroin with different concentration ratios to design a suitable substrate for corneal tissue regeneration. The cross-linked samples were evaluated with different analyses such as structural, physical (optical, swelling, and degradation), mechanical, and biological (viability, cell adhesion) assays.

Network Cluster Analysis of PPI and Phenotype Ontology for Type 1 Diabetes Mellitus.

Background: Our knowledge of Type 1 Diabetes Mellitus (T1DM) etiology is incomplete; however, the pathogenesis of the disease includes T-cell-mediated destruction of β-cells.

Objective: The present study aimed to investigate the key gene pathways and co-expression networks in T1DM disease.

Material And Methods: TIDM-associated genes were identified from 13 databases, enrichment of pathways annotated with functional annotations, and analysis of protein-protein network interactions.

Molecular Dynamics Simulation of Antimicrobial Peptide CM15 in and Model Bilayer Lipid.

Background: In animals and plants, antimicrobial peptides (AMPs) are crucial components of defense mechanisms, as they play a crucial role in innate immunity, which protects hosts from pathogenic bacteria. The CM15 has attracted considerable interest as a novel antibiotic against gram-negative and positive pathogens.

Objective: The aim of this study was to investigate the permeation potential of the CM15 with membrane bilayers of and .

Promoting β-cells function by the recapitulation of in vivo microenvironmental differentiation signals.

The study aims to transdifferentiate rat bone marrow-derived mesenchymal stem cells (BM-MSCs) more efficiently into islet-like cells and encapsulate and transplant them with vital properties like stability, proliferation, and metabolic activity enhanced for the treatment of T1DM. Trans-differentiation of BM-MCs into islet-like cells induced by high glucose concentration combined with Nicotinamide, ꞵ-Mercaptoethanol, ꞵ-Cellulin, and IGF-1. Glucose challenge assays and gene expression profiles were used to determine functionality.

Bacteriostatic Potency of FeO Against in Synergy with Antibiotics by DDST Method.

Background: In this study, bacteriostatic potency of the Iron oxide nanoparticles against ( (a clinical sample and the ATCC11700 strain) was investigated.

Methods: Nanoparticles' bacteriostatic concentration was determined and used to appraise the characteristics of the Iron Oxide (FeO) against the isolates. Antimicrobial examinations with 10 were performed at the baseline.

Structural characterization of PPTI, a kunitz-type protein from the venom of Pseudocerastes persicus.

The main purpose of this report is to investigate the structural property and new potential function of PPTI (Pseudocerastes Persicus Trypsin Inhibitor), a kunitz-type protein with inhibitory effect against trypsin proteolytic activity. Besides kunitz-type serine protease inhibitors, PPTI shows clear-cut similarities with dendrotoxins (DTXs), the other kunitz-type protein subfamily. The most important reason is the presence of functionally important residues of DTXs at correspondingly the same positions in PPTI.

Kinetics activity of Against ZnO Nanoparticles Either Synergism Antibiotics by Double-Disc Synergy Test Method.

Background: Bacterial resistance to the commonly used antibacterial agents is an increasing challenge in the medicine, and a major problem for the health care systems; the control of their spread is a constant challenge for the hospitals.

Objectives: In this study, we have investigated the antimicrobial activity of the Zinc Oxide nanoparticles against clinical sample; bacteria.

Materials And Methods: Nanoparticle susceptibility constants and death kinetic were used to evaluate the antimicrobial characteristics of the Zinc Oxide (ZnO) against the bacteria.