Publications by authors named "Davin Hong"
Article Synopsis
- Drug-resistant parasites are spreading from Southeast Asia to Africa, posing a significant threat to malaria treatment effectiveness.
- Researchers used genetically modified mice to identify key genetic factors that contribute to resistance against two antimalarial drugs, artemisinin (ART) and piperaquine (PPQ), particularly in the dominant KEL1/PLA1 parasite lineage.
- The study findings suggest that the mutant PfCRT gene plays a central role in ART resistance and that PPQ drives the selection of resistant parasites; however, the same mutant may increase susceptibility to a different drug, lumefantrine, offering a potential strategy for combating resistance.
Drug-resistant parasites have swept across Southeast Asia and now threaten Africa. By implementing a genetic cross using humanized mice, we report the identification of key determinants of resistance to artemisinin (ART) and piperaquine (PPQ) in the dominant Asian KEL1/PLA1 lineage. We mapped as the central mediator of ART resistance and identified secondary markers.
View Article and Find Full Text PDFNonmuscle myosin IIB (NMIIB) is a cytoplasmic myosin, which plays an important role in cell motility by maintaining cortical tension. It forms bipolar thick filaments with ~14 myosin molecule dimers on each side of the bare zone. Our previous studies showed that the NMIIB is a moderately high duty ratio (~20-25%) motor.
View Article and Find Full Text PDF