Chemically Synthesized Lipid A as an Adjuvant to Augment Immune Responses to Type B Conjugate Vaccine.

We previously identified spp. as a commensal bacterium that resides in lymphoid tissues, including Peyer's patches. We found that -derived lipopolysaccharide acted as a weak agonist of Toll-like receptor four due to the unique structure of lipid A, which lies in the core of lipopolysaccharide.