First-Line Chemo-Immunotherapy in SCLC: Outcomes of a Binational Real-World Study.

Introduction: SCLC is characterized by aggressiveness and limited treatment options, especially in extensive-stage SCLC (ES-SCLC). Immunotherapy added to the platinum-etoposide combination has recently become standard in this setting. This retrospective study aims to evaluate the real-world effectiveness of chemo-immunotherapy in patients with ES-SCLC, focusing on subpopulations excluded from clinical trials.

The Effective Use by Primary Care Clinicians of a Comprehensive Computerized Insulin Dose Adjustment Algorithm.

Primary care clinicians (PCCs) manage 90% of patients with diabetes, 30% of whom require insulin with a substantial number poorly controlled because of the challenges that PCCs face (time constraints and lack of experience). The author has developed Federal Drug Administration cleared and Conformite Europeenne mark registered comprehensive computerized insulin dose adjustment algorithms (CIDAAs) to enable PCCs to significantly lower HbA1c levels in insulin-requiring patients. Reports sent to PCCs contain scatter plots of glucose readings, their organization into pre- and postprandial and before bedtime values, their analyses, and recommendations for insulin dose adjustments (if indicated) that the PCC can accept or modify.

A survey of quit vaping strategies and relapse triggers for maintaining youth and young adult vaping abstinence in Canada.

Objectives: To examine whether various quit strategies and relapse triggers are associated with maintenance period in a sample of people who quit vaping.

Method: Young Canadians who used to vape ( = 772) completed an online survey on maintenance period, quit strategies, and relapse triggers. Logistic regression was employed to variables associated with maintenance period.

Lorlatinib-associated weight gain and dyslipidaemia: A retrospective analysis and implications for future care.

Objectives: The objective of our study was to benchmark the incidence and severity of lorlatinib-related weight gain and dyslipidaemia in a real-world context, to guide future therapeutic strategies to mitigate these toxicities.

Methods: We conducted a retrospective, observational analysis of patients with ALK and ROS1-positive NSCLC at a single institution in the UK who were commenced on lorlatinib from 11/2016 to 11/2022. Non-small cell lung cancer (NSCLC) patients prescribed lorlatinib were identified through institutional electronic pharmacy records.

Cholesteryl ester transfer protein inhibition: a pathway to reducing risk of morbidity and promoting longevity.

Purpose Of Review: To review the evidence and describe the biological plausibility for the benefits of inhibiting cholesteryl ester transfer protein (CETP) on multiple organ systems through modification of lipoprotein metabolism.

Recent Findings: Results from observational studies, Mendelian randomization analyses, and randomized clinical trials support the potential of CETP inhibition to reduce atherosclerotic cardiovascular disease (ASCVD) risk through a reduction of apolipoprotein B-containing lipoproteins. In contrast, raising high-density lipoprotein (HDL) particles, as previously hypothesized, did not contribute to ASCVD risk reduction.

Intranasal Oxytocin Combined With Social Skills Training for Schizophrenia: An Add-on Randomized Controlled Trial.

Some but not other studies on oxytocin for schizophrenia, particularly those using a higher dose, indicate that oxytocin improves negative symptoms of schizophrenia. We performed an add-on randomized controlled trial to examine the effect of high-dose oxytocin, social skills training, and their combination in the treatment of negative symptoms and social dysfunction in schizophrenia. Fifty-one subjects with schizophrenia were randomized, employing a two-by-two design: intranasal oxytocin (24 IU X3/day) or placebo, and social skills training or supportive psychotherapy, for 3 weeks.

Maximizing the environmental benefits of gas power development in China: A multidisciplinary modeling approach.

China, holding nearly half of the global coal-fired power capacity, must shift from its coal-centric energy system to meet climate and air quality goals. This study explores the optimal utilization of natural gas by evaluating the environmental and economic costs of gas- and coal-fired power using plant-level data and a multidisciplinary modeling approach. We find that gas power has substantially lower air pollution costs (0.

Cultural theory and political philosophy: Why cognitive biases toward ambiguous risk explain both beliefs about nature's resilience and political preferences regarding the organization of society.

Many studies have observed a correlation between beliefs regarding nature's resilience and (political) preferences regarding the organization of society. Liberal-egalitarians, for example, generally believe nature to be much more fragile than libertarians, who believe nature to be much more resilient. Cultural theory explains this correlation by the idea that people are only able to see those risks that fit their preferred organization of society.

Examining personality dimensions in rats using a caregiver questionnaire.

Measures of individual behavioural differences (personality) are highly valuable in many areas of ethology, particularly studies of animal emotion and welfare. However, there are limitations to current behavioural tests of personality. Caregiver questionnaires may provide a complementary approach to overcome some of these limitations and provide a richer insight into personality.

Obicetrapib exhibits favorable physiochemical and pharmacokinetic properties compared to previous cholesteryl ester transfer protein inhibitors: An integrated summary of results from non-human primate studies and clinical trials.

Anacetrapib, a cholesteryl ester transfer protein (CETP) inhibitor previously under development, exhibited an usually extended terminal half-life and large food effect and accumulated in adipose tissue. Other CETP inhibitors have not shown such effects. Obicetrapib, a potent selective CETP inhibitor, is undergoing Phase III clinical development.

You are How You Eat: Foraging Behavior as a Potential Novel Marker of Rat Affective State.

Unlabelled: Effective and safe foraging requires animals to behave according to the expectations they have about the rewards, threats, and costs in their environment. Since these factors are thought to be reflected in the animals' affective states, we can use foraging behavior as a window into those states. In this study, rats completed a foraging task in which they had repeatedly to decide whether to continue to harvest a food source despite increasing time costs, or to forgo food to switch to a different food source.

Delphi Recommendations for Diagnosis and Treatment of Sexual Interest in Children in Non-Mandated Community Settings.

This study sought to reach an international expert consensus regarding the diagnosis and treatment of adults with a sexual interest in children in cases where treatment is non-mandated. An expert panel of 27 participants (19 professionals and eight individuals with sexual interest in children) completed at least one of three rounds of an online Delphi survey. In the first round, participants responded to open-ended questions about assessment approaches, treatment goals, treatment approaches, and adapting assessment and treatment for sexual exclusivity.

In adults with hypertension and high CV risk, intensive vs. standard BP-lowering therapy reduced major vascular events.

Liu J, Li Y, Ge J, et al; ESPRIT Collaborative Group. Lancet. 2024;404:245-255.

Elective pelvic nodal irradiation in the setting of ultrahypofractionated versus moderately hypofractionated and conventionally fractionated radiotherapy for prostate cancer: Outcomes from 3 prospective clinical trials.

Background And Purpose: Data is needed regarding the use of ultrahypofractionated radiotherapy (UHRT) in the context of prostate cancer elective nodal irradiation (ENI), and how this compares to conventionally fractionated radiotherapy (CFRT) ENI with CFRT or moderately hypofractionated radiotherapy (MHRT) to the prostate.

Materials And Methods: Between 2011-2019, 3 prospective clinical trials of unfavourable intermediate or high-risk prostate cancer receiving CFRT (78 Gy in 39 fractions to prostate; 46 Gy in 23 fractions to pelvis), MHRT (68 Gy in 25 fractions to prostate; 48 Gy to pelvis), or UHRT (35-40 Gy in 5 fractions to prostate +/- boost to 50 Gy to intraprostatic lesion; 25 Gy to pelvis) were conducted. Primary endpoints included biochemical failure (Phoenix definition), and acute and late toxicities (CTCAE v3.

Agar lot-specific inhibition in the plating efficiency of yeast spores and cells.

The fission yeast Schizosaccharomyces pombe and the budding yeast Saccharomyces cerevisiae are highly diverged (530 mya), single-celled, model eukaryotic organisms. Scientists employ mating, meiosis, and the plating of ascospores and cells to generate strains with novel genotypes and to discover biological processes. Our three laboratories encountered independently sudden-onset, major impediments to such research.

A methamphetamine vaccine using short monoamine and diamine peptide linkers and poly-mannose.

Methamphetamine (METH) substance use disorder is a long-standing and ever-growing public health concern. Efforts to develop successful immunotherapies are ongoing with vaccines that generate strong antibody responses are an area of significant research interest. Herein, we describe the development of a METH Hapten conjugate vaccine comprised of either two short-length peptides as linkers and mannan as an immunogenic delivery carrier.

Facile Synthesis of a Novel Furanic Monomer and Its ADMET Polymerization toward Fully Renewable Functional Polymers.

Efficient and sustainable transformation of biomass-derived chemicals to materials with the potential to replace conventional fossil-derived polymers is considered a major challenge. In this work, we disclose the synthesis of a novel furan-based α,ω-diene monomer following a facile, green, and energy-efficient process from fully renewable starting materials. The multifunctional monomer was produced by the base-catalyzed cross-aldol condensation of 10-undecenal (UA) and 2,5-diformylfuran (DFF) under mild conditions, providing the desired product in good yields.

Clinical symptoms and psychosocial functioning in patients with schizophrenia spectrum disorders testing seropositive for anti-NMDAR antibodies: a case-control comparison with patients testing negative.

Background: Antibodies against the N-methyl-D-aspartate receptor (NMDAR) have been described in the serum of people with schizophrenia spectrum disorders (schizophrenia). However, the prevalence and clinical relevance of these antibodies in schizophrenia is unclear. This knowledge gap includes the possibility of such antibodies being associated with a distinct clinical profile, which in turn might warrant a distinct treatment approach.