Localization of human A, B and H isoantigens in Cynomolgus monkey tissues.

The presence and distribution of human A, B and H isoantigens were demonstrated in Cynomolgus monkey (Macaca fascicularis) by means of red cell adherence test. Although no human antigens were found on primate erythrocytes, various epithelial tissues revealed the presence of A, B or H antigenic substance. The distribution and localization was similar to that found in human tissues.

The cell surface antigens of bladder washing specimens in patients with bladder tumors, a new approach.

The blood group antigens A, B and O(H) are present on the cell surface of many tissues, including the urothelium. It has been shown that loss of these antigens from the surface of tumor cells correlated with subsequent development of invasion. Since the specific red cell adherence test demonstrates the presence or absence of these antigens the test may have an important prognostic and screening value.

Blood group isoantigen deletion in carcinoma in situ of the urinary bladder.

Blood group isoantigens A and H (O) were measured by the Secific Red Cell Adherence (SRCA) Test in nine radical cystectomy specimens removed from patients with extensive carcinoma in situ of the urinary bladder. All bladders had areas of histologically normal epithelium and areas of epithelial atypia in addition to the carcinoma in situ. In eight cases, tissue-associated blood group isoantigens were deleted in areas showing either atypia or carcinoma in situ.

Isoantigen ABH in cervical intraepithelial neoplasia.

The purpose of the study was to examine the relationship between the histologic findings and the presence or absence of ABH isoantigens in intraepithelial neoplasia of the cervix. After the lesions were graded by four pathologists, the Red Cell Adherence (RCA) test was done to demonstrate the ABH antigens, and the results of the two were compared. The correlation between the morphologic diagnosis and the results of the RCA test was limited.

Horse agglutinins in infectious mononueleosis. 3. riterion for differential diagnosis.

One hundred infectious mononucleosis and the same number of non-infectious mononucleosis sera were studied to evaluate the sensitivity and specificity of horse erythrocytes in the diagnosis of infectious mononucleosis. Titres of horse agglutinins in infectious mononucleosis sera ranged from 28 to 7,168 with a geometric mean of 550, whereas the corresponding sheep agglutinin titres ranged from less than 7 to 3,584, with a geometric mean of 126. Horse agglutinin titres of non-infectious mononucleosis sera ranged from less than 7 to 896, with a geometric mean of 59.