Effectiveness of mid-regional pro-adrenomedullin, compared to other biomarkers (including lymphocyte subpopulations and immunoglobulins), as a prognostic biomarker in COVID-19 critically ill patients: New evidence from a 15-month observational prospective study.

Background: Mid-regional pro-adrenomedullin (MR-proADM), an endothelium-related peptide, is a predictor of death and multi-organ failure in respiratory infections and sepsis and seems to be effective in identifying COVID-19 severe forms. The study aims to evaluate the effectiveness of MR-proADM in comparison to routine inflammatory biomarkers, lymphocyte subpopulations, and immunoglobulin (Ig) at an intensive care unit (ICU) admission and over time in predicting mortality in patients with severe COVID-19.

Methods: All adult patients with COVID-19 pneumonia admitted between March 2020 and June 2021 in the ICUs of a university hospital in Italy were enrolled.

Proadrenomedullin in the Management of COVID-19 Critically Ill Patients in Intensive Care Unit: A Systematic Review and Meta-Analysis of Evidence and Uncertainties in Existing Literature.

Mid-regional proadrenomedullin (MR-proADM) is a new biomarker of endothelial damage and its clinical use is increasing in sepsis and respiratory infections and recently in SARS-CoV-2 infection. We conducted a systematic review and meta-analysis to clarify the use of MR-proADM in severe COVID-19 disease. After Pubmed, Embase, and Scopus search, registries, and gray literature, deduplication, and selection of full-texts, we found 21 studies addressing the use of proadrenomedullin in COVID-19.

Improved BSM sensitivity in diboson processes at linear colliders.

We study and final sstates at future linear colliders; designing analyses specific to the various final state polarizations allows us to target specific beyond the Standard Model (BSM) effects, parametrized in the form of dimension-6 operators. We find that CLIC can access effects roughly an order of magnitude smaller than HL-LHC or ILC, and two orders of magnitude smaller than LEP. These results are interpreted in the context of well-motivated BSM scenarios-at weak and strong coupling-where we expect correlated effects in Drell-Yann processes.

Measuring Higgs Couplings without Higgs Bosons.

The measurement of Higgs couplings constitutes an important part of present standard model precision tests at colliders. We show that modifications of Higgs couplings induce energy-growing effects in specific amplitudes involving longitudinally polarized vector bosons, and we initiate a novel program to study these effects off shell and at high energy, rather than on the Higgs resonance. Our analysis suggests that these channels are complementary and competitive with familiar on-shell measurements; moreover, they offer endless opportunities for refinement and improvements.