PCOS is a widespread endocrine disorder affecting up to 20% of reproductive-aged women, with unclear causes, where the composition of follicular fluid may differ from the norm.
Researchers utilized ELISA assays and metabolomic analysis to assess levels of vasoactive intestinal peptide (VIP) and other hormones in follicular fluids and plasma.
Findings revealed increased VIP levels in PCOS patients' follicular fluids, highlighting a correlation with Anti-Müllerian Hormone and suggesting a potential disruption in sympathetic regulation within ovarian follicles, implicating VIP in both ovarian function and PCOS pathophysiology.