Publications by authors named "Davide Barteselli"
Article Synopsis
- Adams-Oliver syndrome is a rare genetic condition marked by scalp defects and limb abnormalities, linked to mutations in specific genes.
- A recent study identified a new genetic variant that likely causes limb anomalies, predicting that it leads to a dysfunctional protein due to a significant change in its structure.
- The research highlights the importance of interdisciplinary approaches combining experimental and bioinformatics analyses to deepen the understanding of genetic disorders like Adams-Oliver syndrome and their varying impacts on patients.
Brown adipocytes are unique in that they expend energy and produce heat to maintain euthermia through expression of uncoupling protein-1 (UCP1). Given their propensity to stimulate weight loss and promote resistance to obesity, they are a compelling interventional target for obesity-related disorders. Here, we tested whether an optogenetic approach could be used to activate UCP1-dependent thermogenesis in brown adipocytes.
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