Publications by authors named "David de Saint Gilles"

Article Synopsis
  • Early diagnosis of kidney damage after lung transplantation is crucial due to its negative impact on patient prognosis.
  • A study analyzed 100 kidney biopsies from lung transplant patients, finding that chronic renal dysfunction was the main reason for biopsy, revealing a variety of chronic kidney lesions.
  • Key factors linked to the risk of progressing to end-stage renal disease included postoperative dialysis, high levels of proteinuria, and significant glomerulosclerosis, highlighting the need for timely nephrologist referrals.
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Introduction: Pink urine syndrome is a rare, poorly understood condition, often prompted by obesity, insulin resistance, and the drug propofol. It is characterized by pink urine or urine sediment and occurs in the absence of a heme or food-based pigment. The pathophysiology of this syndrome is not yet fully understood but is linked to a uric acid metabolism disorder.

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Aim: For patients with end-stage kidney disease, living-donor kidney transplantation is the best therapy. There is a duty to ensure that the donor is followed-up after donation on a regular and long-term basis. Conditions may arise, such as hypertension, chronic kidney disease, metabolic conditions, and these should be identified and treated as soon as possible for the donor's own longer term wellbeing.

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Looking at the urine for diagnostic purposes, once performed by ancient Egyptians, can still provide some valuable clues in modern medicine. Several diseases have been named after their associated urine color and this underlines the clinical value of visual urine inspection: blue diaper disease, purple urine bag syndrome, black urine disease or porphyria. Abnormal urine color could be challenging for the clinician: it may reveal neoplastic disease (urologic cancer; melanoma), cell lysis (rhabdomyolysis; hemolysis), infection (lymphatic filariasis; malaria), enzyme deficiency (porphyria; alkaptonuria), medication or food intake.

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