Publications by authors named "David Zuza"

Article Synopsis
  • * Traditional methods of measuring IDR often overlook important details such as the influence of particle shape, fluid movement, and how crystals dissolve differently based on their size and surface characteristics.
  • * This study used advanced time-resolved X-ray microtomography to observe and analyze how NaCl crystals of various sizes dissolve in a controlled environment, providing valuable insights into the individual and collective dissolution behaviors of particles.
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A new approach for testing drug sensitivity to autooxidative degradation in the solid state is demonstrated in this work. A novel solid-state form of stressing agent for autooxidation has been proposed, based on azobisisobutyronitrile loaded into mesoporous silica carrier particles. The new solid-state form of the stressing agent was applied in degradation studies of two active pharmaceutical ingredients: bisoprolol and abiraterone acetate.

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The sorption of poorly aqueous soluble active pharmaceutical ingredients (API) to mesoporous silica carriers is an increasingly common formulation strategy for dissolution rate enhancement for this challenging group of substances. However, the success of this approach for a particular API depends on an array of factors including the properties of the porous carrier, the loading method, or the attempted mass fraction of the API. At present, there is no established methodology for the rational selection of these parameters.

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