Publications by authors named "David Xthona Lee"
BACKGROUNDVaccination is typically administered without regard to site of prior vaccination, but this factor may substantially affect downstream immune responses.METHODSWe assessed serological responses to initial COVID-19 vaccination in baseline seronegative adults who received second-dose boosters in the ipsilateral or contralateral arm relative to initial vaccination. We measured serum SARS-CoV-2 spike-specific Ig, receptor-binding domain-specific (RBD-specific) IgG, SARS-CoV-2 nucleocapsid-specific IgG, and neutralizing antibody titers against SARS-CoV-2.
View Article and Find Full Text PDFArticle Synopsis
- * This study explored the effects of a heterologous vaccine boost in two CLL patients who had inadequate responses to their initial mRNA vaccinations.
- * Results showed that one patient developed strong immune responses, including antibodies and specific T-cells, while the other did not, indicating that a third dose could enhance immune response in some CLL patients who initially struggled.
Article Synopsis
- Current COVID-19 vaccines significantly lower illness and death rates, playing a crucial role in managing the pandemic.
- Individuals who have recovered from COVID-19 and then get vaccinated show stronger immune responses ("hybrid immunity") compared to those who are vaccinated without previous infection.
- Research indicates that both vaccinated individuals with breakthrough infections and those with hybrid immunity produce similar neutralizing antibody levels against various SARS-CoV-2 variants, suggesting that prior infection enhances the overall immune response post-vaccination.
Article Synopsis
- CLL patients often face severe immune dysfunction, making standard COVID-19 vaccines less effective, prompting the exploration of a heterologous boost for those who didn't respond to the initial vaccine series.
- Two CLL patients were observed in a study after receiving a third dose of a different COVID-19 vaccine (Ad26.COV2.S) to assess their immune response.
- Following this third dose, one patient showed a positive immune response with significant antibody and T-cell production, while the other did not demonstrate similar improvements.