Evidence for the influence of testosterone in the performance of spatial navigation in a virtual water maze in women but not in men.

Testosterone (T) may be associated with enhanced spatial navigation in a number of rodent species, although the nature of the relation is equivocal. Similarly, numerous studies in humans generally have found that T is associated with enhanced spatial ability on a variety of paper and pencil tasks that may relate to navigational ability. However, relatively few studies have reported effects of T on navigational ability in humans.

Mycobacterium marinum tenosynovitis in a patient on etanercept therapy for rheumatoid arthritis.

Opportunistic infections are a theoretical concern with the use of tumor necrosis factor antagonists, as these agents can impair host immunity. A 61-year-old man with rheumatoid arthritis being treated with only etanercept (soluble tumor necrosis factor receptor) and in remission from the rheumatoid arthritis presented with dorsal tenosynovitis of his right wrist. The synovitis was not improved by a local corticosteroid injection.

Radiography and US of os peroneum fractures and associated peroneal tendon injuries: initial experience.

Purpose: To retrospectively evaluate the imaging features of os peroneum fractures and associated peroneus longus tendon injuries at radiography and ultrasonography (US) and to retrospectively compare these imaging features with those of multipartite os peroneum.

Materials And Methods: Institutional review board approval was obtained and informed consent was waived for this HIPAA-compliant study. Retrospective review of findings in nine patients (five men, four women; age range, 35-59 years) with os peroneum fracture at radiography and lateral foot pain after injury who had undergone US of the foot was performed.

Personal information in searching for faces.

Participants searched for a target on a television monitor either after they viewed pictures and received physical information about the target or received that information augmented by personal information. Based on a levels of processing perspective we predicted that the addition of personal information would stimulate deeper processing and result in better identification performance. Personal information did increase identification accuracy, as anticipated.

Evidence for time-place learning in the Morris water maze without food restriction but with increased response cost.

Time-place learning is the ability to distinguish between resources that vary in location at different times of day. Only one previous report has demonstrated successful time-place learning without using food as reward. In this experiment, satiated rats failed to form time-place discriminations in a Morris water maze while food deprived rats did, leading to the conclusion that food system activation is necessary for time-place learning.

Autoimmune disease complicating antiviral therapy for hepatitis C virus infection.

Objective: To review autoimmune disease complicating therapy with type I interferons (IFNs), specifically in the setting of hepatitis C virus (HCV) infection.

Methods: This study describes 13 reported cases of drug-induced systemic lupus erythematosus (SLE) associated with IFN therapy for the period reported during 1990-2002 by searching MEDLINE. In addition, 2 additional patients are presented, 1 with SLE and 1 with an antineutrophil cytoplasmic antibody (ANCA)-positive nephritis, with long-term follow-up.

Longitudinal stress fracture: patterns of edema and the importance of the nutrient foramen.

Design And Patients: We reviewed the MR appearances of six cases of longitudinal stress fracture of the lower extremity.

Results: One fracture was in the femur and five were in the tibia. Four of the tibial fractures showed edema starting in the mid-tibia at the level of the nutrient foramen with the fracture on the anteromedial cortex.

Conditioned inhibitory effects of discriminated Pavlovian training with food in rats depend on interactions of search modes, related repertoires, and response measures.

Like other accounts of conditioned inhibition, behavior systems predicts (and Experiment 1 shows) that during summation and retardation tests, presentation of a negative conditioned stimulus (a CS-) created by discriminative Pavlovian food conditioning will interfere with a focal search response, such as nosing in the feeder. Unlike most other views, behavior systems predicts (and Experiment 2 shows) that the same CS- can potentiate a general search response, like attending to a moving artificial prey stimulus. Contacting the prey stimulus in extinction increased over baseline when a CS- but not a CS Novel preceded it.