Publications by authors named "David W Niebuhr"

The American Lung Association's "State of the Air" 2023 report reveals almost 36% of Americans live with unhealthy levels of air pollution. Studies link air pollution with acute respiratory symptoms and exacerbation of respiratory and cardiovascular diseases. Differential air pollution exposures between white and nonwhite communities are significant components of environmental injustices.

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  • Understanding the connection between Epstein-Barr virus (EBV) and multiple sclerosis (MS) remains challenging, focusing on why only some infected individuals develop the disease.
  • The study aimed to analyze the immune response to EBV peptides in individuals before they showed MS symptoms, seeing if a distinct immune reaction correlates with the disease onset.
  • Results indicated that people with MS had a stronger overall antibody response to EBV peptides, particularly those related to EBNA antigens, although specific patterns varied.
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Background: Smoking is a well-established risk factor for MS; however, it is not known whether its effect on disease risk varies by race/ethnicity.

Methods: We conducted a nested case-control study among US military personnel who have serum samples stored at the Department of Defense Serum Repository. We measured serum cotinine levels, a marker of tobacco smoke exposure, in 157 Black and 23 White individuals who developed MS during follow-up.

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Introduction: Childhood adversity profoundly influences health, well-being, and longevity. Prevention and interventions to mitigate its harmful effects are essential. The American College of Preventive Medicine reviewed the research literature and other professional and governmental statements about adverse childhood experiences to support the development of evidence-based and population-focused recommendations about prevention, screening, and mitigation interventions for childhood adversity.

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  • MS is a chronic disease affecting the central nervous system, and researchers investigated whether Epstein-Barr virus (EBV) is a potential cause in a study of over 10 million US military personnel.
  • The study found that individuals who were infected with EBV had a 32-fold increased risk of developing MS compared to those infected with other viruses, including cytomegalovirus.
  • Additionally, levels of neurofilament light chain, which indicates nerve damage, only increased after individuals became infected with EBV, supporting the idea that EBV may be a primary factor in causing MS.
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Importance: Unrecognized demyelinating events often precede the clinical onset of multiple sclerosis (MS). Identification of these events at the time of occurrence would have implications for early diagnosis and the search of causal factors for the disease.

Objective: To assess whether serum neurofilament light chain (sNfL) levels are elevated before the clinical MS onset.

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Introduction: The health impact of the heterozygous (Hb Ss) Sickle Cell Trait (SCT) among the estimated one million females of reproductive age in the United States on pregnancy related hypertensive disorders (PRHD) including preeclampsia is not as well understood or researched as Sickle Cell Disease (SCD).

Materials And Methods: This retrospective cohort study included 25,020 U.S.

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Background: Severe upper limb injuries (SULI) may pose a significant public health challenge for the military; however, SULI has not been previously defined or studied in the US military. Objective: Determine SULI incidence, risk factors, and outcomes.

Materials And Methods: Active Component (AC) U.

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Introduction: E-cigarettes or or electronic nicotine delivery systems (ENDS) have rapidly gained popularity in the U.S. Controversy exists about the safety and efficacy of ENDS.

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Introduction: Sickle cell trait (SCT), the heterozygous carrier state for hemoglobin S, is present in an estimated 1.6% of all newborns and 7.3% in black individuals in the USA.

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  • - Sickle cell trait (SCT) prevalence in the U.S. military is approximately 5.02% in non-Hispanic blacks, with variations in screening and occupational policies across different military branches.
  • - A study analyzed over 75,000 active duty personnel from 1992 to 2013, finding that SCT-positive individuals were deployed more frequently and served longer compared to those without the trait.
  • - Although no significant differences in overall mortality rates were found, SCT-positive members showed higher instances of death from suicide and other non-specific causes, indicating a need for further research on the impact of SCT in military settings.
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Introduction: A number of studies have found an association between sickle cell trait (SCT) and exertional heat illnesses (EHIs) including heat stroke, a potentially fatal condition. The strength of this association varied across studies, limiting the ability to quantify potential benefits of SCT-screening policies for competitive athletics and military service members. We determined the relative rate and attributable risk of developing EHI associated with being SCT positive and the EHI health care utilization.

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Low-grade inflammation is present in some cases of schizophrenia, particularly in the early stages of this disorder. The inflammation source is not known but may be the result of dysbiotic processes occurring in the gut. We examined peripheral biomarkers of bacterial translocation, soluble CD14 (sCD14) and lipopolysaccharide binding protein (LBP), and of general inflammation, C-reactive protein (CRP), in a unique, pre-onset study of schizophrenia.

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Background: Population-based estimates of sickle cell trait (SCT) prevalence in the U.S. military across services and over time are lacking.

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Background: The incidence of obstructive sleep apnea (OSA) in the military has risen dramatically. OSA is considered "service connected" and compensable by the Veterans Administration. The association between body mass index (BMI) (kg/m(2)) measured at initial enlistment and development of OSA has yet to be assessed.

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The American College of Preventive Medicine Prevention Practice Committee contributes to policy guidelines and recommendations on preventive health topics for clinicians and public health decision makers. After review of the currently available evidence, the College is providing a consensus-based set of recommendations designed to increase screening for and prevention of hepatitis C virus infection, increase linkage to care, improve access to treatment, and encourage development of hepatitis C virus-related quality measures.

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  • Bipolar disorder (BD) is often misdiagnosed, leading to ineffective treatments, which prompted the investigation of a biomarker panel for accurate diagnosis.
  • A meta-analysis of eight studies identified a panel with 20 protein biomarkers that showed strong predictive capabilities in distinguishing BD from other mental health disorders.
  • The findings suggest that using this biomarker panel can significantly improve early and accurate diagnosis, potentially delaying or preventing the onset of bipolar disorder.
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Biomarkers have been examined in schizophrenia research for decades. Medical morbidity and mortality rates, as well as personal and societal costs, are associated with schizophrenia patients. The identification of biomarkers and alleles, which often have a small effect individually, may help to develop new diagnostic tests for early identification and treatment.

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Alterations in immune response may be an important component in the etiopathogenesis of schizophrenia and bipolar disorder. We examined the associations of pentraxin-3 (PTX3) with the onset of schizophrenia or bipolar disorder. We tested preonset serum specimens from 160 US military service members who were later diagnosed with schizophrenia or bipolar disorder and 160 matched controls without psychiatric disorders.

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Background: Each time a deployed military member has an exacerbation of a pre-existing chronic disease there is a potential risk to mission success, individual health, and the safety of the unit. Currently, North Atlantic Treaty Organization (NATO) member nations employ different approaches to assessing an individual's medical fitness for deployment.

Objective: To set the minimum medical standards for NATO deployments.

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Study Design: Matched case-control epidemiological study.

Objective: To identify pre-enlistment, demographic, and service-related risk factors for back-related disability in enlisted US soldiers and Marines comparing those who were deployed with those who did not deploy during the service term.

Summary Of Background Data: Back conditions are a major cause of morbidity and lost work days in both the US working population and military.

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Objective: To determine risk factors for disability retirement in Air Force personnel, as well as the conditions contributing to disability retirement.

Methods: A matched case-control study was conducted. Air Force personnel with accession records who were disability retired between 2002 and 2011 were included as cases.

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Introduction: Multiple studies have documented immune activation in many individuals with schizophrenia suggesting that antigens capable of generating a prolonged immune response may be important environmental factors in many cases of this disorder. While existing studies have found single-agent associations of antibodies to food and neurotropic infectious agents with schizophrenia, a simultaneous examination of multiple agents may shed light on agent interactions or possible etiopathogenic pathways.

Methods: We used traditional regression and novel statistical techniques to examine associations of single and combined infectious and food antigens with schizophrenia.

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