Publications by authors named "David W Newstrom"
Article Synopsis
- B cells play a crucial role in systemic lupus erythematosus (SLE) and lupus nephritis (LN), with antinuclear antibodies present in nearly all SLE patients; targeting spleen tyrosine kinase (SYK) may help manage these conditions.
- A study evaluated lanraplenib, a selective oral SYK inhibitor, on human B cells in vitro and NZB/W mice in vivo, measuring its impact on kidney health and immune response.
- Results showed lanraplenib inhibited B cell activation, improved mouse survival, reduced proteinuria and kidney damage, and lowered inflammation markers, indicating its potential as a therapeutic option for lupus-related diseases.
Estrogen-receptor alpha (ERα) neurons in the ventrolateral region of the ventromedial hypothalamus (VMHVL) control an array of sex-specific responses to maximize reproductive success. In females, these VMHVL neurons are believed to coordinate metabolism and reproduction. However, it remains unknown whether specific neuronal populations control distinct components of this physiological repertoire.
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