Publications by authors named "David W Cuthbertson"

Myeloid sarcoma is a rare extramedullary tumor composed of malignant myeloid cells that occur in the presence of myeloid leukemia. We report a case series of pediatric head and neck myeloid sarcomas representative of the epidemiology, symptomatology, laboratorial correlations, prognoses, and treatment of extramedullary leukemia. Presented are 3 cases involving patients ranging from 17 months to 11 years of age.

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Importance: Basal cell adenocarcinoma (BCAC) of the minor salivary gland is an extremely rare disease: the most recent substantive literature review reports only 25 cases. Owing to the rarity of this disease, it has not yet been well characterized in the literature.

Objective: We sought to expand the knowledge of minor salivary gland BCAC by performing an exhaustive literature review and adding to it a new case that is rare owing to the tumor's size, aggressive nature, and mixed histologic pattern.

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Primitive Myxoid Mesenchymal Tumor of Infancy (PMMTI) is a recently recognized locally aggressive myofibroblastic tumor. It is a low- to intermediate-grade fibroblastic malignancy with a high local recurrence rate but low metastatic potential and is composed of primitive spindled cells in a myxoid background. We present the eleventh reported case of PMMTI, occurring in the sinonasal tract of a 3-year old child.

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Objectives/hypothesis: To determine the degree to which balance is impaired by fatigue in postcall medical residents and to assess the validity of posturography in quantifying that impairment.

Study Design: Prospective study.

Methods: Medical residents underwent the following tests before and immediately after overnight call: 1) computerized dynamic posturography (CDP) using the Equitest force platform (Natus Medical Inc.

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Article Synopsis
  • The study investigates the interaction between NR2F1, a nuclear receptor, and microRNAs (miRNAs) in the development of the inner ear.
  • Using a bioinformatic method, researchers identified 11 potential miRNAs that may work with NR2F1, with a focused analysis revealing that miR-140 is significantly down-regulated in NR2F1 knockout mice's inner ear.
  • Experimental validation demonstrated a direct regulatory network involving NR2F1, miR-140, and KLF9, suggesting complex coregulation is essential for inner ear development and function.
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