Nanoscale Colocalization of NK Cell Activating and Inhibitory Receptors Controls Signal Integration.

Natural killer (NK) cell responses depend on the balance of signals from inhibitory and activating receptors. However, how the integration of antagonistic signals occurs upon NK cell-target cell interaction is not fully understood. Here we provide evidence that NK cell inhibition the inhibitory receptor Ly49A is dependent on its relative colocalization at the nanometer scale with the activating receptor NKG2D upon immune synapse (IS) formation.

Meiothermus rufus sp. nov., a new slightly thermophilic red-pigmented species and emended description of the genus Meiothermus.

Four red-pigmented isolates, with optimum growth temperatures of approximately 55-60 degrees C and an optimum pH for growth between 7.5 and 8.5, were recovered from hot springs in Central France.