Publications by authors named "David Thiam En Lim"
The interaction of unfractionated heparin (UFH) with universal heparin reversal agent 7 (UHRA-7) is investigated. UHRA-7 is composed of a hyperbranched polyglycerol core onto which an array of methylated tris(2-aminoethylamine) (Me-TREN) charged groups is grafted, which in turn are shielded with a layer of small chain poly(ethylene glycol) methyl ether (mPEG) chains. This system has previously been shown to be biocompatible and to be effective at neutralizing heparin.
View Article and Find Full Text PDFNovel active Trp- and Arg-rich antimicrobial peptides with high solubility and low red blood cell toxicity designed using machine learning tools.
Bridget A B Henson Fucong Li José Ausencio Álvarez-Huerta Poornima G Wedamulla Arianna Valdes Palacios David Thiam En Lim
Int J Antimicrob Agents
December 2024
Article Synopsis
- * Machine learning techniques were used to identify and rank potential non-hemolytic AMPs from two libraries of peptide sequences, leading to the synthesis and testing of 220 peptides against Methicillin-resistant Staphylococcus aureus (MRSA).
- * Six promising AMPs were further analyzed for their effectiveness against various bacteria and cancer cell lines, revealing a successful strategy for creating effective and safe antimicrobial agents, while also setting a foundation for future research and machine learning applications in peptide design.