A partial gene deletion of SLC45A2 causes oculocutaneous albinism in Doberman pinscher dogs.

The first white Doberman pinscher (WDP) dog was registered by the American Kennel Club in 1976. The novelty of the white coat color resulted in extensive line breeding of this dog and her offspring. The WDP phenotype closely resembles human oculocutaneous albinism (OCA) and clinicians noticed a seemingly high prevalence of pigmented masses on these dogs.

A survey of ocular abnormalities in miniature horses.

Objective: To determine the incidence of ocular abnormalities in miniature horses.

Design: Descriptive study.

Animals Studied: Fifty-three miniature horses.

Targeted analysis of four breeds narrows equine Multiple Congenital Ocular Anomalies locus to 208 kilobases.

The syndrome Multiple Congenital Ocular Anomalies (MCOA) is the collective name ascribed to heritable congenital eye defects in horses. Individuals homozygous for the disease allele (MCOA phenotype) have a wide range of eye anomalies, while heterozygous horses (Cyst phenotype) predominantly have cysts that originate from the temporal ciliary body, iris, and/or peripheral retina. MCOA syndrome is highly prevalent in the Rocky Mountain Horse but the disease is not limited to this breed.

Equine Multiple Congenital Ocular Anomalies maps to a 4.9 megabase interval on horse chromosome 6.

Background: Equine Multiple Congenital Ocular Anomalies (MCOA) syndrome consists of a diverse set of abnormalities predominantly localized to the frontal part of the eye. The disease is in agreement with a codominant mode of inheritance in our horse material. Animals presumed to be heterozygous for the mutant allele have cysts originating from the temporal ciliary body, peripheral retina and/or iris.

Assessment of corneal thickness, intraocular pressure, optical corneal diameter, and axial globe dimensions in Miniature Horses.

Objective: To determine corneal thickness, intraocular pressure (IOP), and horizontal and vertical corneal diameter (HCD and VCD) and to obtain axial measurements of the anterior chamber depth (ACD), crystalline lens thickness (CLT), vitreous chamber depth (VtCD), and axial globe length (AGL) in eyes of Miniature Horses.

Animals: 41 healthy Miniature Horses.

Procedure: Ocular component measurements were obtained via ultrasonic pachymetry, applanation tonometry, ultrasound, and by use of a Jameson caliper.

Early postnatal development of central corneal thickness in dogs.

Objective: To investigate the changes in corneal thickness that occur during maturation of the canine eye over the first months of life.

Animals Studied: Dogs of two different breeds with ages ranging from 14 days to 42 weeks of age.

Procedures: The central corneal thickness was measured by ultrasonic pachymetry every week for the first month after eyelid opening (around 14 days) and then every month until 42 weeks of age.

A quantitative assessment of TPP-induced delayed neuropathy in the retina and lateral geniculate nucleus of the European ferret (Mustela putorius furo).

Triphenyl phosphite (TPP) has been examined extensively in our lab to assess its degenerative effects on the visual pathway of the European ferret. Tanaka et al. [Fundam.