Metformin and Micronutrient Status in Type 2 Diabetes: Does Polypharmacy Involving Acid-Suppressing Medications Affect Vitamin B12 Levels?

Metformin is the first-choice drug in uncomplicated type 2 diabetes (T2DM) and is effective in improving glycaemic control. It is the most widely prescribed oral antidiabetic medicine and has a good safety profile. However, there is an abundance of evidence that metformin use is associated with decreased Vitamin B12 status, though the clinical implications of this in terms of increased risk of diabetic peripheral neuropathy are debated.

Quantification of Movement Characteristics in Women's English Premier Elite Domestic Rugby Union.

This study aims were to determine the positional physical requirements of English domestic women's rugby union match-play. Global positioning system data (Catapult Minimax S4) were collected at 10 Hz of 129 competitive player games from the Tyrrells Premier15 league. Players were classified according to broad (Forwards, Backs) and specific positions (front-, second-, back-row, scrum-half, inside-, and outside-backs).

Effect of the PreBind Engagement Process on Scrum Timing and Stability in the 2013-16 Six Nations.

This study examined whether changes in scrum engagement laws from the "crouch-touch-set" in 2013 to the "PreBind" engagement from 2014 onward have led to changes in scrum characteristics, specifically timing, in international rugby union. Duration and outcomes were identified for all scrums occurring in the 2013-16 Six Nations (N = 60 games) using video analysis. Scrum duration increased after the introduction of the PreBind engagement from 59 s in 2013 to 69 s in 2016 (P = .

Differentiating technical skill and motor abilities in selected and non-selected 3-5 year old team-sports players.

This study examined the difference in 22 3-5year old boys selected to an advanced or non-advanced group on an English community-based professional club training program. Time to complete 15m linear sprint and 15m zig-zag agility tests, with and without a ball, were used to assess the children's technical skill and motor ability. Age and body mass of both groups were the same, whereas height was greater and BMI was lower in the selected group (p<0.

Tier-specific evolution of match performance characteristics in the English Premier League: it's getting tougher at the top.

This study investigated the evolution of physical and technical performances in the English Premier League (EPL), with special reference to league ranking. Match performance observations (n = 14,700) were collected using a multiple-camera computerised tracking system across seven consecutive EPL seasons (2006-07 to 2012-13). Final league rankings were classified into Tiers: (A) 1st-4th ranking (n = 2519), (B) 5th-8th ranking (n = 2965), (C) 9th-14th ranking (n = 4448) and (D) 15th-20th ranking (n = 4768).

Factors influencing physical and technical variability in the English Premier League.

Purpose: To investigate match-to-match variability of physical and technical performances in English Premier League players and quantify the influence of positional and contextual factors.

Methods: Match data (N = 451) were collected using a multicamera computerized tracking system across multiple seasons (2005-06 to 2012-13). The coefficient of variation (CV) was calculated from match to match for physical and technical performances in selected positions across different match contexts (location, standard, and result).

Evolution of match performance parameters for various playing positions in the English Premier League.

This study aimed to investigate position-specific evolution of physical and technical performance parameters in the English Premier League (EPL). Match performance observations (n=14700) were collected using a multiple-camera computerized tracking system across seven seasons (2006-07 to 2012-13). Data were analyzed relative to five playing positions: central defenders (n=3792), full backs (n=3420), central midfielders (n=3200), wide midfielders (n=2136) and attackers (n=2152).

Increased variability of lap speeds: differentiating medalists and nonmedalists in middle-distance running and swimming events.

Purpose: Previous literature has presented pacing data of groups of competition finalists. The aim of this study was to analyze the pacing patterns displayed by medalists and nonmedalists in international competitive 400-m swimming and 1500-m running finals.

Methods: Split times were collected from 48 swimming finalists (four 100-m laps) and 60 running finalists (4 laps) in international competitions from 2004 to 2012.

Reliability and stability of performances in 400-m swimming and 1500-m running.

Purpose: To assess the reliability and stability of 400-m swimming and 1500-m running competitions to establish the number of samples needed to obtain a stable pacing profile. Coaches, athletes, and researchers can use these methods to ensure that sufficient data are collected before training and race strategies are constructed or research conclusions are drawn.

Method: Lap times were collected from 5 world and European championship finals between 2005 and 2011, resulting in the capture of data from 40 swimmers and 55 runners.

Validity and reliability of a 1500-m lap-time collection method using public videos.

The collection of retrospective lap times from video footage is a potentially useful research tool to analyze the pacing strategies in any number of competitive events. The aim of this study was to validate a novel method of obtaining running split-time data from publically available video footage. Videos of the 1500-m men's final from the 2004 and 2008 Olympics, 2005 and 2009 World Championships, and 2010 European Championships were obtained from the YouTube Web site, and split times were collected from all competitors using frame-by-frame playback.

The effects of fluid restriction on hydration status and subjective feelings in man.

Hydration status and the effects of hypohydration have been the topic of much public and scientific debate in recent years. While many physiological responses to hypohydration have been studied extensively, the subjective responses to hypohydration have largely been ignored. The present investigation was designed to investigate the physiological responses and subjective feelings resulting from 13, 24 and 37 h of fluid restriction (FR) and to compare these with a euhydration (EU) trial of the same duration in fifteen healthy volunteers.