Publications by authors named "David Skvasik"
Article Synopsis
- Focal cortical dysplasia (FCD) is a key cause of hard-to-treat epilepsy, and this study explored how glucose metabolism is affected in different FCD types by studying GLUT1 expression and DNA methylation changes.
- Researchers found that hypermethylation of glucose-regulating genes can differentiate FCD subtypes from other conditions and that lower GLUT1 levels are linked to increased levels of VEGFα and MCT2.
- Decitabine treatment showed potential to restore glucose uptake and alter gene expression related to metabolism in brain cells, suggesting new pathways for developing biomarkers and early treatment strategies for FCD.
Recurrent chronic mucosal inflammation, a characteristic of inflammatory bowel diseases (IBD), perturbs the intestinal epithelial homeostasis resulting in formation of mucosal wounds and, in most severe cases, leads to colitis-associated colon cancer (CAC). The altered structure of epithelial cell-cell adhesions is a hallmark of intestinal inflammation contributing to epithelial injury, repair, and tumorigenesis. P-cadherin is an important adhesion protein, poorly expressed in normal intestinal epithelial cells (IEC) but upregulated in inflamed and injured mucosa.
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