Purpose: FAPI ligands (fibroblast activation protein inhibitor), a novel class of radiotracers for PET/CT imaging, demonstrated in previous studies rapid and high tumor uptake. The purpose of this study is the head-to-head intra-individual comparison of Ga-FAPI versus standard-of-care F-FDG in PET/CT in organ biodistribution and tumor uptake in patients with various cancers.
Material And Methods: This international retrospective multicenter analysis included PET/CT data from 71 patients from 6 centers who underwent both Ga-FAPI and F-FDG PET/CT within a median time interval of 10 days (range 1-89 days).
Purpose: The positive predictive power for malignancy can potentially be improved, if the chemical compositions of suspicious breast lesions can be reliably measured in screening mammography. The purpose of this study is to investigate the feasibility of quantifying breast lesion composition, in terms of water and lipid contents, with spectral mammography.
Methods: Phantom and tissue samples were imaged with a spectral mammography system based on silicon-strip photon-counting detectors.