Enantioselective Pd -Catalyzed C(sp )-H Arylation for the Synthesis of Chiral Warped Molecules.

C-H activation-based ring-forming methods are a powerful approach for the construction of complex molecular architectures, especially those containing a congested stereocenter. Therefore, this strategy seems perfectly suited to address the synthesis of chiral polycyclic aromatic hydrocarbons (PAHs) and bowl-shaped molecules, which are important target molecules in the field of organic electronic materials. Herein, we describe an enantioselective Pd -catalyzed C(sp )-H arylation protocol for the synthesis of chiral fluoradenes and other warped molecules, which could serve to the bottom-up construction of chiral PAHs.