Autoimmune retinopathy associated with systemic lupus erythematosus: A diagnostic dilemma.

Visual loss in systemic lupus erythematosus (SLE) due to autoimmune retinopathy (AIR) is rare and easily misdiagnosed as hydroxychloroquine retinopathy. We report the rare clinical presentation of severe visual loss in a patient with SLE due to nonparaneoplastic AIR as differentiated from hydroxychloroquine toxicity. A 70-year-old female diagnosed and treated for lupus for 17 years and had been taking hydroxychloroquine for 15 years.

Treat-and-Extend Therapy Using Aflibercept for Neovascular Age-related Macular Degeneration: A Prospective Clinical Trial.

Purpose: To determine the efficacy and durability of aflibercept used in a treat-and-extend (TAE) regimen for neovascular age-related macular degeneration (NVAMD).

Design: Multicenter, prospective, open label, noncomparative, interventional study.

Methods: Forty eyes of 40 patients with treatment-naïve NVAMD were managed with a TAE regimen of intravitreal aflibercept.

Analysis of Choroidal and Retinal Vasculature in Inherited Retinal Degenerations Using Optical Coherence Tomography Angiography.

Background And Objective: To describe the retinal vasculature and choriocapillaris, as well as the transition zone between the diseased and healthy tissue, in eyes with inherited retinal degenerations using optical coherence tomography angiography (OCTA).

Patients And Methods: Patients with inherited retinal degenerations were recruited for OCTA imaging. Retinal vasculature was assessed for increased intercapillary space and foveal avascular zone abnormalities.

DETECTION OF MICROVASCULAR CHANGES IN EYES OF PATIENTS WITH DIABETES BUT NOT CLINICAL DIABETIC RETINOPATHY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Purpose: To evaluate the ability of optical coherence tomography angiography to detect early microvascular changes in eyes of diabetic individuals without clinical retinopathy.

Methods: Prospective observational study of 61 eyes of 39 patients with diabetes mellitus and 28 control eyes of 22 age-matched healthy subjects that received imaging using optical coherence tomography angiography between August 2014 and March 2015. Eyes with concomitant retinal, optic nerve, and vitreoretinal interface diseases and/or poor-quality images were excluded.

Visualization of the Retinal Vasculature Using Wide-Field Montage Optical Coherence Tomography Angiography.

Background And Objective: To evaluate the technique of wide-field montage optical coherence tomography angiography (OCTA) for improved visualization of the retinal vasculature in the posterior pole.

Patients And Methods: In this prospective case series, five eyes (three healthy and two diseased) of three patients were imaged using a novel technique to create wide-field montage OCTA images by combining nine 3 × 3-mm OCTA scans from the prototype AngioVue software of the RTVue XR (Optovue, Fremont, CA). Features seen on montage OCTA were compared to those visualized on fluorescein angiography (FA) and single-scan 8 × 8-mm OCTA.

Oral eplerenone for treatment of chronic central serous chorioretinopathy: a case series.

Background And Objective: To evaluate the effect of oral eplerenone on subretinal fluid, visual acuity, and choroidal thickness in patients with chronic central serous chorioretinopathy (CSCR).

Patients And Methods: Retrospective review of all patients (14 eyes of 14 patients) monitored for a minimum of 3 months with chronic CSCR who were treated with oral eplerenone in a single multi-physician retina practice. Visual acuity, dilated funduscopic examination, and spectral-domain ocular coherence tomography (OCT) with enhanced depth imaging (EDI) were obtained at each visit.

Imaging in diabetic retinopathy.

While the primary method for evaluating diabetic retinopathy involves direct and indirect ophthalmoscopy, various imaging modalities are of significant utility in the screening, evaluation, diagnosis, and treatment of different presentations and manifestations of this disease. This manuscript is a review of the important imaging modalities that are used in diabetic retinopathy, including color fundus photography, fluorescein angiography, B-scan ultrasonography, and optical coherence tomography. The article will provide an overview of these different imaging techniques and how they can be most effectively used in current practice.

Publication rates of registered clinical trials in macular degeneration.

Purpose: The purpose of this study was to evaluate the rate of publication of registered clinical trials concerning age-related macular degeneration (AMD).

Methods: The National Institutes of Health's ClinicalTrials.gov registry was searched to identify all trials concerning AMD.