Publications by authors named "David R Hurwitz"
Article Synopsis
- The COVID-19 pandemic has raised concerns for patients with chronic diseases, particularly those with preexisting conditions that may worsen COVID-19 outcomes, like ATTR amyloidosis.
- ATTR amyloidosis leads to the buildup of amyloid fibrils in various organs, causing issues like heart problems and nerve damage, making patients with this condition especially vulnerable to complications during COVID-19.
- There is a need for further research on the risk and management of COVID-19 in ATTR amyloidosis patients, as they may require special care due to their increased risk of severe outcomes.
Microbial transglutaminase (MTG) was stably solid-phase immobilized on glass microbeads by using a second-generation dendronized polymer. Immobilized MTG enabled the efficient generation of site-specifically conjugated proteins, including antibody fragments, as well as whole antibodies through distinct glutamines and, unprecedentedly, also through lysines with various bifunctional substrates with defined stoichiometries. With this method, we generated dual, site-specifically modified antibodies comprising a fluorescent probe and a metal chelator for radiolabeling-a strategy anticipated to design antibodies for imaging and simultaneous therapy.
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