It's all about making new contacts: How being metabotropic and phasicity help D1-like receptors promote LTP in the PFC.

D1-like receptors have two important qualities, they are all metabotropic and they activate with phasic dopamine. After analyzing the molecular implications of each of these qualities separately and then combining them for the specific case of the prefrontal cortex, we propose a model that explains why long term potentiation in this cortical area depends on the amount of contact between D1-like receptors and dopamine. This simple model also explains why in order to promote long term potentiation, dopamine transporters should be scarce in the prefrontal cortex.

Neurological soft signs (NSS) and gray matter volume (GMV) in first-episode psychosis: An analysis of NSS motor subscores.

We aimed to study the correlations between gray matter volume and the motor subscores of NSS in first-episode psychosis patients with both, whole brain and region of interest analyses. The structural MRIs of 81 first-episode psychosis patients were analyzed by using voxel-based morphometry (VBM) for SPM. NSS were assessed using the Heidelberg scale.

Working memory maintenance is sufficient to reduce state anxiety.

According to the attentional control theory (ACT) proposed by Eysenck and colleagues, anxiety interferes with cognitive processing by prioritizing bottom-up attentional processes over top-down attentional processes, leading to competition for access to limited resources in working memory, particularly the central executive (Eysenck, Derakshan, Santos, & Calvo, ). However, previous research using the n-back working memory task suggests that working memory load also reduces state anxiety. Assuming that similar mechanisms underlie the effect of anxiety on cognition, and the effect of cognition on anxiety, one possible implication of the ACT would suggest that the reduction of state anxiety with increasing working memory load is driven by activation of central executive attentional control processes.

Mental fatigue impairs emotion regulation.

Because healthy physical and mental functioning depends on the ability to regulate emotions, it is important to identify moderators of such regulations. Whether mental fatigue, subsequent to the depletion of cognitive resources, impairs explicit emotion regulation to negative stimuli is currently unknown. This study explored this possibility.