A CNN-based four-layer DOI encoding detector using LYSO and BGO scintillators for small animal PET imaging.

. We propose a novel four-layer depth-of-interaction (DOI) encoding phoswich detector using lutetium-yttrium oxyothosilicate (LYSO) and bismuth germanate (BGO) scintillator crystal arrays for high sensitivity and high spatial resolution small animal PET imaging..

A digital phoswich detector using time-over-threshold for depth of interaction in PET.

We present the performance of a digital phoswich positron emission tomography (PET) detector, composed by layers of pixilated scintillator arrays, read out by solid state light detectors and an application specific integrated circuit (ASIC). We investigated the use of integrated charge from the scintillation pulses along with time-over-threshold (ToT) to determine the layer of interaction (DOI) in the scintillator. Simulations were performed to assess the effectiveness of the ToT measurements for separating the scintillator events and identifying cross-layer-crystal-scatter (CLCS) events.

Performance evaluation of HiPET, a high sensitivity and high resolution preclinical PET tomograph.

HiPET is a recently developed prototype preclinical PET scanner dedicated to high sensitivity and high resolution molecular imaging. The HiPET system employs a phoswich depth of interaction (DOI) detector design, which also allows identification of the large majority of the cross layer crystal scatter (CLCS) events. This work evaluates its performance characteristics following the National Electrical Manufacturers Association (NEMA) NU4-2008 protocol.

Performance Evaluation of G8, a High-Sensitivity Benchtop Preclinical PET/CT Tomograph.

G8 is a benchtop integrated PET/CT scanner dedicated to high-sensitivity and high-resolution imaging of mice. This work characterizes its National Electrical Manufacturers Association NU 4-2008 performance where applicable and also assesses the basic imaging performance of the CT subsystem. The PET subsystem in G8 consists of 4 flat-panel detectors arranged in a boxlike geometry.

MARS: a mouse atlas registration system based on a planar x-ray projector and an optical camera.

This paper introduces a mouse atlas registration system (MARS), composed of a stationary top-view x-ray projector and a side-view optical camera, coupled to a mouse atlas registration algorithm. This system uses the x-ray and optical images to guide a fully automatic co-registration of a mouse atlas with each subject, in order to provide anatomical reference for small animal molecular imaging systems such as positron emission tomography (PET). To facilitate the registration, a statistical atlas that accounts for inter-subject anatomical variations was constructed based on 83 organ-labeled mouse micro-computed tomography (CT) images.

Investigation of OPET Performance Using GATE, a Geant4-Based Simulation Software.

A combined optical positron emission tomography (OPET) system is capable of both optical and PET imaging in the same setting, and it can provide information/interpretation not possible in single-mode imaging. The scintillator array here serves the dual function of coupling the optical signal from bioluminescence/fluorescence to the photodetector and also of channeling optical scintillations from the gamma rays. We report simulation results of the PET part of OPET using GATE, a Geant4 simulation package.