Accuracy of I Na Thyroid Imaging in calculating thyroid volume.

Hyperthyroidism is often managed with radioactive iodine therapy. The dose of Iadministered to the patient is determined based on the calculated size of the thyroid gland in gram and 24 hour iodine uptake. Ultrasonography is a validated modality for determination of thyroid volume.

Esophageal Oligometastases of the Foot.

Acrometastasis is a rare clinical entity, estimated to represent less than 0.3% of all bone metastases. Here, we present a case of esophageal cancer that was treated with esophagectomy, chemotherapy, and radiation therapy and developed oligometastases of the foot after 8 years in remission.

Thyroid Scintigraphy of a Rare Case of Left Thyroid Lobe Hemiagenesis With Subacute Thyroiditis.

Thyroid hemiagenesis is a rare developmental anomaly. Patients with thyroid hemiagenesis have higher incidence of coexisting thyroid disorders in the remaining lobe. We present a rare case of a 21-year-old woman with subclinical hyperthyroidism incidentally found to have thyroid hemiagenesis on thyroid 123I-Na scan, which is confirmed on thyroid ultrasound.

False-Positive 123I-Uptake Mimics Metastatic Lung Disease in a Patient With Interstitial Lung Disease Secondary to Scleroderma.

A 59-year-old woman with a history of papillary thyroid cancer status post total thyroidectomy and 131I ablation therapy presented with lower back pain and leg weakness. MRI of the lumbar spine revealed homogenously enhancing lesions at L1-L2 and L3-L4. Subsequent whole-body 123I-Na scan demonstrated significant 123I retention in the mid to distal esophagus, as well as diffuse uptake in basal segments of the lungs bilaterally.

Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.

Chronic inflammation drives the progression of colorectal cancer (CRC). Increased expression of interleukin (IL)-17A is associated with poor prognosis, and IL-17A blockade curbs tumor progression in preclinical models of CRC. Here we examined the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment.

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells.

Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patients with sickle cell disease and some forms of β-thalassemia. To identify potentially druggable HbF regulators in adult human erythroid cells, we employed a protein kinase domain-focused CRISPR-Cas9-based genetic screen with a newly optimized single-guide RNA scaffold. The screen uncovered the heme-regulated inhibitor HRI (also known as EIF2AK1), an erythroid-specific kinase that controls protein translation, as an HbF repressor.

Anti-inflammatory natural product goniothalamin reduces colitis-associated and sporadic colorectal tumorigenesis.

The tumor microenvironment offers multiple targets for cancer therapy, including pro-tumorigenic inflammation. Natural compounds represent an enormous source of new anti-inflammatory and anticancer agents. We previously showed that the styryl lactone goniothalamin (GTN) has promising antiproliferative and anti-inflammatory activities.