Publications by authors named "David Perez-Villaroya"
Background: Previous evidence indicates associations between the female reproductive tract microbiome composition and reproductive outcome in infertile patients undergoing assisted reproduction. We aimed to determine whether the endometrial microbiota composition is associated with reproductive outcomes of live birth, biochemical pregnancy, clinical miscarriage or no pregnancy.
Methods: Here, we present a multicentre prospective observational study using 16S rRNA gene sequencing to analyse endometrial fluid and biopsy samples before embryo transfer in a cohort of 342 infertile patients asymptomatic for infection undergoing assisted reproductive treatments.
Article Synopsis
- Scientists studied bacteria in the female reproductive system using new techniques and found that a type of bacteria called Lactobacillus is usually the most common.
- Changes in these bacteria might be linked to problems like not being able to get pregnant or losing a pregnancy early on.
- The study compared bacteria before a miscarriage and during a healthy pregnancy, discovering different kinds of Lactobacillus and noting that in healthy pregnancies, the bacterial community seemed to protect and support pregnancy better.
Article Synopsis
- People living at high altitudes, like the Sherpa in Nepal and the Aymara in Bolivia, have changed over time to survive with less oxygen and food.
- Scientists studied how these people's gut bacteria are different from those living at low altitudes, like some Europeans.
- The unique gut bacteria found in high-altitude populations help them get important nutrients and adapt better to the tough living conditions up high.
Investigation of the microbial community in the female reproductive tract has revealed that the replacement of a community dominated by with pathogenic bacteria may be associated with implantation failure or early spontaneous abortion in patients undergoing assisted reproductive technology (ART) treatment. Herein we describe taxonomically and functionally the endometrial microbiome of an infertile patient with repeated reproductive failures (involving an ectopic pregnancy and two clinical miscarriages). The microbiological follow-up is presented over 18-month in which the microbiota was evaluated in six endometrial fluid samples.
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