Concordance between LDL-C estimated by various formulas and directly measured LDL-C.

Background: Although direct measurement of LDL cholesterol (LDL-C) in blood is possible, there are several formulas for its estimation. The performance and concordance of these formulas have not been evaluated in Colombia.

Objective: To determine the concordance between LDL-C directly measured using the enzymatic technique and existing methods to calculate it.

Clinical and neurophysiological characteristics of patients with Guillain-Barré syndrome at Hospital Universitario San Ignacio, Bogotá, Colombia between 2009 and 2017.

Guillain-Barré syndrome (GBS) is the most common acute peripheral polyneuropathy in the world. The estimated incidence in Colombia is 1.2-1.

Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility.

Key Points: Electrical pacemaking in gastrointestinal muscles is generated by specialized interstitial cells of Cajal that produce the patterns of contractions required for peristalsis and segmentation in the gut. The calcium-activated chloride conductance anoctamin-1 (Ano1) has been shown to be responsible for the generation of pacemaker activity in GI muscles, but this conclusion is established from studies of juvenile animals in which effects of reduced Ano1 on gastric emptying and motor patterns could not be evaluated. Knocking down Ano1 expression using Cre/LoxP technology caused dramatic changes in in gastric motor activity, with disrupted slow waves, abnormal phasic contractions and delayed gastric emptying; modest changes were noted in the small intestine.

The cells and conductance mediating cholinergic neurotransmission in the murine proximal stomach.

Key Points: Enteric neurotransmission is essential for gastrointestinal (GI) motility, although the cells and conductances responsible for post-junctional responses are controversial. The calcium-activated chloride conductance (CaCC), anoctamin-1 (Ano1), was expressed by intramuscular interstitial cells of Cajal (ICC-IM) in proximal stomach and not resolved in smooth muscle cells (SMCs). Cholinergic nerve fibres were closely apposed to ICC-IM.

Management of the Pine Processionary Moth, Thaumetopoea pityocampa (Lepidoptera: Thaumetopoeidae), in Urban and Suburban Areas: Trials With Trunk Barrier and Adhesive Barrier Trap Devices.

In urban and suburban areas larvae of the pine processionary moth, Thaumetopoea pityocampa (Denis and Schiffermüller), cause serious defoliation to Cedrus, Pinus, and Pseudotsuga trees and health problems to humans and domestic or farm animals by their urticating setae. In this study, we present the results of biennial trials (2015-2016) on the management of T. pityocampa infestations using commercial or LIFE-PISA prototype trunk barrier and adhesive trap devices in Greece (Attica and Volos), Spain (Valencia), and Italy (Molise).

TWO-WAY Bridge between Muscular Dysfunction and Cognitive Impairment: Secondary Analyses of SABE - Bogota Study.

Background And Objective: Muscular dysfunction and cognitive impairment are both disabling states, affecting especially the elderly. Thus, are important subjects of research. Our goal is to describe the association between these two entities in the elderly.

Association of Fatigue With Sarcopenia and its Elements: A Secondary Analysis of SABE-Bogotá.

Sarcopenia, fatigue, and depression are associated with higher mortality rates and adverse outcomes in the aging population. Understanding the association among clinical variables, mainly symptoms, is important for screening and appropriately managing these conditions. The aim of this article is to evaluate the association among sarcopenia and its elements with depression and fatigue.

Evaluation of Pheromone Trap Devices for the Capture of Thaumetopoea pityocampa (Lepidoptera: Thaumetopoeidae) in Southern Europe.

The development of reliable monitoring techniques can offer valuable sources of knowledge on the control of Thaumetopoea pityocampa (Denis and Schiffermüller) (Lepidoptera: Thaumetopoeidae). Nevertheless, there is a knowledge gap on the simultaneous large-scale monitoring of T. pityocampa male adult population by using novel trap devices.

Fourier finite element modeling of light emission in waveguides: 2.5-dimensional FEM approach.

We present a Fourier finite element modeling of light emission of dipolar emitters coupled to infinitely long waveguides. Due to the translational symmetry, the three-dimensional (3D) coupled waveguide-emitter system can be decomposed into a series of independent 2D problems (2.5D), which reduces the computational cost.

A hybrid method for inversion of 3D DC resistivity logging measurements.

This paper focuses on the application of hierarchic genetic strategy (-HGS) for solution of a challenging problem, the inversion of 3D direct current (DC) resistivity logging measurements. The problem under consideration has been formulated as the global optimization one, for which the objective function (misfit between computed and reference data) exhibits multiple minima. In this paper, we consider the extension of the -HGS strategy, namely we couple the -HGS algorithm with a gradient based optimization method for a local search.

CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.

Embryonic stem cells (ESCs) have adopted an accelerated cell-cycle program with shortened gap phases and precocious expression of cell-cycle regulatory proteins, including cyclins and cyclin-dependent kinases (CDKs). We examined the effect of CDK inhibition on the pathways regulating proliferation and survival of ESCs. We found that inhibiting cyclin-dependent kinase 1 (CDK1) leads to activation of the DNA damage response, nuclear p53 stabilization, activation of a subset of p53 target genes including NOXA, and negative regulation of the anti-apoptotic protein MCL1 in human and mouse ESCs, but not differentiated cells.

Psychiatric disorders in children and adolescents six-to-twelve months after mild traumatic brain injury.

The objective of this study was to understand how novel psychiatric disorders (NPD) in children with mild traumatic brain injury (MTBI) are related to pre-injury variables, injury-related variables, and concurrent neurocognitive outcome. A group of 79 children, ages 5 to 14 years, who had experienced MTBI, were studied from consecutive hospital admissions with semistructured psychiatric interviews soon after injury (baseline); 60 children were reassessed 12 months post-injury. Standardized instruments were used to assess injury severity; lesion characteristics; pre-injury variables, including psychiatric disorder, family psychiatric history, family functioning, socioeconomic status, psychosocial adversity, adaptive functioning, and post-injury neurocognitive and adaptive functioning.