Publications by authors named "David Papworth"
Genomic instability is observed in tumors and in a large fraction of the progeny surviving irradiation. One of the best-characterized phenotypic manifestations of genomic instability is delayed chromosome aberrations. Our working hypothesis for the current study was that if genomic instability is in part attributable to cis mechanisms, we should observe a non-random distribution of chromosomes or sites involved in instability-associated rearrangements, regardless of radiation quality, dose, or trans factor expression.
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- Genomic imprinting leads to the silencing of specific gene alleles based on whether they come from the mother or the father, regulated by special regions that can affect nearby genes significantly.
- Researchers have identified two important regions that control imprinting in the Gnas gene cluster on mouse chromosome 2, finding that one region affects the expression of Gnas itself while the other may influence related transcripts.
- A study showed that deleting a specific methylation region linked to paternal expression of Gnas can reverse certain abnormalities in mice with a maternal Gnas mutation, indicating a complex control system for this gene and its neighbors.
The principal objectives of intraoperative monitoring are to improve perioperative outcome, facilitate surgery and reduce adverse events, using continuously collected data of cardiopulmonary,neurologic and metabolic function to guide pharmacologic and physiologic therapy. Although sophisticated and reliable apparatus may be used to collect these data they are useless, or even harmful, without proper interpretation. This article provides a comprehensive overview of recent publications on the history,philosophy, and semantics of monitoring.
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