Publications by authors named "David Papazian"
Front Pharmacol
April 2022
Article Synopsis
- - Limb-girdle muscular dystrophy type R3 (LGMD R3) is a genetic disorder resulting from mutations in the alpha-sarcoglycan (α-SG) gene, leading to muscle weakness.
- - Researchers conducted a study to find drugs that enhance the effectiveness of the proteasome inhibitor bortezomib in degrading the misfolded R77C-α-SG protein, identifying the HDAC inhibitor givinostat as a promising candidate.
- - Givinostat's therapeutic action appears to inhibit the autophagic pathway, suggesting new insights into how misfolded SG proteins are degraded and indicating potential for treating other diseases with similar degradation issues.
