Publications by authors named "David Packman"
The UK National Institute for Health and Care Excellence (NICE) considered evidence for voretigene neparvovec (VN; Luxturna) for the treatment of RPE65-mediated inherited retinal dystrophies (IRD) within its highly specialised technology programme. This paper summarises the evidence provided by the company; the appraisal of the evidence by the Peninsula Technology Appraisal Group, who were commissioned to act as the independent evidence review group (ERG); and the development of the NICE guidance by the appraisal committee. The evidence presented by the company highlighted the significant lifelong burden of IRD for patients and carers.
View Article and Find Full Text PDFBackground: Preterm birth may result in short- and long-term health problems for the child. Accurate diagnoses of preterm births could prevent unnecessary (or ensure appropriate) admissions into hospitals or transfers to specialist units.
Objectives: The purpose of this report is to assess the test accuracy, clinical effectiveness and cost-effectiveness of the diagnostic tests PartoSure™ (Parsagen Diagnostics Inc.
Article Synopsis
- The study addresses the challenges of modeling population dynamics in fluctuating environments, highlighting the importance of incorporating short-term transient effects rather than just focusing on long-term equilibrium models.
- The research utilizes a mathematical concept called non-normality to analyze the ability of population projection matrices to amplify fluctuations, revealing that non-normality has increased in European populations since 1960.
- The paper critiques existing reliance on inadequate analytical methods for transient dynamics and introduces pseudospectra analysis as a more effective tool for understanding population fluctuations and informing policy decisions.
We revisit the question of when can dispersal-induced coupling between discrete sink populations cause overall population growth? Such a phenomenon is called dispersal driven growth and provides a simple explanation of how dispersal can allow populations to persist across discrete, spatially heterogeneous, environments even when individual patches are adverse or unfavourable. For two classes of mathematical models, one linear and one non-linear, we provide necessary conditions for dispersal driven growth in terms of the non-existence of a common linear Lyapunov function, which we describe. Our approach draws heavily upon the underlying positive dynamical systems structure.
View Article and Find Full Text PDF