Publications by authors named "David P Serota"

Article Synopsis
  • The study focuses on a Comprehensive-TeleHarm Reduction (C-THR) intervention aimed at improving HIV prevention services for people who inject drugs (PWID) through syringe services programs (SSP) in Miami, Florida.
  • The CHARIOT trial will involve 350 PWID participants who will be randomly assigned to receive either C-THR or standard clinic referrals, with the goal of increasing engagement in HIV prevention methods like PrEP and medications for opioid use disorder.
  • The outcomes will be assessed over 12 months, focusing on factors such as engagement, effectiveness, cost-effectiveness, and barriers to implementing the C-THR intervention.
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Article Synopsis
  • - Xylazine, an alpha-2 adrenergic agonist, has become a contaminant in fentanyl and is associated with naloxone-resistant overdoses and unusual wounds in drug users; a unique case in Florida involved a woman with xylazine-induced wounds confirmed through a test strip at a syringe services program.
  • - The woman, 43, presented to a student-run clinic for care of multiple ulcerations on her forearms, and after receiving treatment, she returned seven weeks later with worsening wounds; xylazine was confirmed in her urine during this second visit.
  • - Many people who use drugs (PWUD) struggle to access traditional healthcare due to stigma and lack of insurance, highlighting the urgent need for improved access
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Background: Tele-harm reduction (THR) is a telehealth-enhanced, peer-led, harm reduction intervention delivered within a trusted syringe services program (SSP) venue. The primary goal of THR is to facilitate linkage to care and rapid, enduring virologic suppression among people who inject drugs (PWID) with HIV. An SSP in Miami, Florida, developed THR to circumvent pervasive stigma within the traditional healthcare system.

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Article Synopsis
  • A study conducted at a student-run clinic in Miami found that 55.9% of patients who inject drugs tested positive for xylazine in their urine samples.
  • The presence of xylazine was linked to factors such as unsheltered homelessness, wounds, and positive tests for hepatitis C, fentanyl, and MDMA.
  • The findings highlight the growing prevalence of xylazine in the Southeastern U.S. and emphasize the need for better screening to address associated risks for people who inject drugs.
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Article Synopsis
  • The "undetectable = untransmittable (U = U)" concept has changed how HIV is treated and prevented, with studies defining "undetectable" as having an HIV viral load (VL) under 200 copies/mL.
  • More sensitive tests now detect VLs as low as 20 copies/mL, causing confusion about what it means to be "undetectable" and their implications for transmission risk.
  • The authors argue that reporting these very low VLs is potentially harmful, advocate for better guidelines on VL reporting and counseling, and call for research to address the issues with overly sensitive testing.
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Article Synopsis
  • - Xylazine, an alpha-2 adrenergic receptor agonist, is increasingly found in fentanyl, causing naloxone-resistant overdoses and chronic wounds in people who inject drugs (PWID), as highlighted in a unique case study in Florida.
  • - A 43-year-old woman with severe opioid and stimulant use disorders presented with worsening ulcerations on her forearms at a syringe services program (SSP), where xylazine was confirmed in her urine using a test strip.
  • - The case underscores the critical need for accessible healthcare for PWID, particularly around xylazine-related issues, and emphasizes the importance of developing guidelines for treating related wounds, as many do not seek traditional healthcare due to barriers. *
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Objectives: Based on increasing drug overdose deaths and a shortage of healthcare professionals trained in the management of opioid use disorder (OUD), it is imperative to improve health professional education in addiction medicine. This small group learning exercise and patient panel was designed to provide first year medical students with insights into the lives of people with OUD-through a lens of harm reduction-and to connect biomedical knowledge to the core values and professional themes of their doctoring courses.

Methods: Facilitators were assigned to each small group of 8 students for the harm reduction-centered Long and Winding Road small group case exercise.

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Article Synopsis
  • The study explored a telehealth-based intervention for improving access to buprenorphine treatment among people who inject drugs (PWID) with opioid use disorder during the pandemic.
  • A total of 109 participants engaged in the intervention, and the three-month retention rate for buprenorphine was found to be 58.7%.
  • Factors positively influencing retention included telehealth provider visits and receiving increasing doses of buprenorphine, while a history of stimulant use negatively impacted retention rates.
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Background: The resurgence of HIV outbreaks and rising prevalence among people who inject drugs (PWID) remain exigent obstacles to Ending the HIV Epidemic in the USA. Adapting a low threshold, comprehensive treatment model for PWID with HIV can leverage syringe services programs (SSPs) to increase availability and accessibility of antiretrovirals (ART), medications for opioid use disorder (MOUD), and hepatitis C cure. We developed Tele-Harm Reduction, a telehealth-enhanced, harm reduction intervention delivered within an SSP venue.

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Background: Hospitalizations for severe injection drug use-related infections (SIRIs) are characterized by high costs, frequent patient-directed discharge, and high readmission rates. Beyond the health system impacts, these admissions can be traumatizing to people who inject drugs (PWID), who often receive inadequate treatment for their substance use disorders (SUD). The Jackson SIRI team was developed as an integrated infectious disease/SUD treatment intervention for patients hospitalized at a public safety-net hospital in Miami, Florida in 2020.

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Background: To address the infectious disease (ID) and substance use disorder (SUD) syndemic, we developed an integrated ID/SUD clinical team rooted in harm reduction at a county hospital in Miami, Florida. The Severe Injection-Related Infection (SIRI) team treats people who inject drugs (PWID) and provides medical care, SUD treatment, and patient navigation during hospitalization and after hospital discharge. We assessed the impact of the SIRI team on ID and SUD treatment and healthcare utilization outcomes.

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Introduction: A recent surge in HIV outbreaks, driven by the opioid and stimulant use crises, has destabilized our progress toward targets set forth by Ending the HIV Epidemic: A Plan for America for the high-priority community of people who inject drugs (PWID), particularly Black PWID.

Methods: In order to ascertain the acceptability and feasibility of using a mobile syringe services program (SSP) for comprehensive HIV prevention via PrEP and medications for opioid use disorder (MOUD), our mixed methods approach included a quantitative assessment and semi-structured qualitative interviews with Black PWID (n = 30) in Miami-Dade County who were actively engaged in mobile syringe services.

Results: Participants felt that delivery of MOUD and PrEP at a mobile SSP would be both feasible and acceptable, helping to address transportation, cost, and stigma barriers common within traditional healthcare settings.

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Background: Despite the proven efficacy of medications for opioid use disorder (MOUD) and recent reduction in barriers to prescribers, numerous obstacles exist for patients seeking MOUD. Prior studies have used telephone surveys to investigate pharmacy-related barriers to MOUD. We applied this methodology to evaluate inpatient and outpatient pharmacy barriers to MOUD in South Florida.

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Introduction: The overdose crisis remains a critical public health problem, creating an urgent need to train physicians in the treatment and management of opioid use disorder (OUD). Our medicine clerkship module aimed to close this gap by training and assessing students' motivational interviewing skills, harm reduction knowledge, and use of nonstigmatizing language in the treatment of patients with OUD.

Methods: We evaluated the impact of a small-group, case-based activity and patient panel on the clinical documentation skills of students in a medicine clerkship.

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Background: The dynamics of injection drug use and higher-risk sexual practices compound the risk of HIV and HCV acquisition. Published literature on people who inject drugs (PWID) has examined risk of infection assuming homogeneity of cohort behavior. Categorizing subgroups by injection and sexual risk can inform a more equitable approach to how syringe services programs (SSPs) adapt harm reduction resources and implementation of evidence-based interventions.

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Introduction: During the first year of the COVID-19 pandemic, over 93,000 Americans lost their lives to a preventable overdose. Medications for opioid use disorder (OUD) have been shown to decrease mortality in OUD but are underutilized. Through this case-based learning exercise, first-year medical students applied physiologic and pharmacologic principles to the diagnosis and treatment of OUD.

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Background: People who inject drugs (PWID) have been a marginalized and a stigmatized population since the beginning of the AIDS epidemic and have not experienced the same life-changing benefits of antiretroviral therapy as others. Tele-Harm Reduction (THR) is a telehealth-enhanced, harm reduction intervention, delivered within a trusted SSP venue. It aims to facilitate initiation of care and achieve rapid HIV viral suppression among PWID living with HIV.

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Introduction: Hospitalizations for severe injection-related infections (SIRI), such as endocarditis, osteomyelitis, and skin and soft tissue infections (SSTI) are increasingly common. People who inject drugs (PWID) experiencing SIRIs often receive inadequate substance use disorder (SUD) treatment and lack of access to harm reduction services. This translates into lengthy hospitalizations with high rates of patient-directed discharge, readmissions, and post-hospitalization mortality.

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Article Synopsis
  • * A study found that about one-third of YBMSM who initially declined PrEP later decided to initiate it after 1-14 months, highlighting that their concerns did not completely disappear but shifted over time.
  • * By analyzing interviews, researchers discovered that there isn't a single factor influencing PrEP uptake; instead, health practitioners should view discussions about PrEP as ongoing and focus on promoting its benefits rather than just addressing concerns.
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Background: Newly reported hepatitis C virus (HCV) infections in California increased 50% among people 15-29 years of age between 2014 and 2016. National estimates suggest this increase was due to the opioid epidemic and associated increases in injection drug use. However, most of California's 61 local health jurisdictions (LHJs) do not routinely investigate newly reported HCV infections, so these individuals' risk factors for infection are not well understood.

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Objectives: The COVID-19 pandemic led to the closure of the IDEA syringe services program medical student-run free clinic in Miami, Florida. In an effort to continue to serve the community of people who inject drugs and practice compassionate and non-judgmental care, the students transitioned the clinic to a model of TeleMOUD (medications for opioid use disorder). We describe development and implementation of a medical student-run telemedicine clinic through an academic medical center-operated syringe services program.

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Article Synopsis
  • The study investigates the impact of opioid and stimulant use on hospitalizations for infection-related issues among people who inject drugs (PWID) in Florida.
  • Findings reveal that among 22,856 hospitalizations, opioid use was predominant (73%), but stimulant use is significant, affecting 43% of cases and showing a higher associated risk of in-hospital mortality (26% more likely compared to opioid-only users).
  • The research suggests that while opioid use drives most infections, rising stimulant use also contributes and underscores the need for more harm reduction strategies and focused research on managing stimulant-related infections.
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