Publications by authors named "David P Hedrick"
In this review, the authors discuss a brief history of the Impella mechanical circulatory support device, a mechanistic role for the device in the context of the underlying pathophysiology of acute myocardial infarction cardiogenic shock (AMI-CS), the current body of literature evaluating its role in AMI-CS, and upcoming efforts to identify a role more clearly for the device in AMI-CS.
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- The study investigates the effectiveness of revascularization combined with optimal medical therapy (OMT) versus OMT alone for patients with stable ischemic heart disease (SIHD), using a Bayesian approach to assess risks.
- Out of several trials reviewed, the findings indicate minimal differences in all-cause and cardiac mortality rates between the two treatment options, suggesting that revascularization does not significantly improve these outcomes.
- However, revascularization may lead to lower risks of heart attacks and unstable angina, while also increasing the likelihood of stroke compared to OMT alone.
Importance: The coronavirus disease 2019 (COVID-19) pandemic has resulted in severe psychological, social, and economic stress in people's lives. It is not known whether the stress of the pandemic is associated with an increase in the incidence of stress cardiomyopathy.
Objective: To determine the incidence and outcomes of stress cardiomyopathy during the COVID-19 pandemic compared with before the pandemic.
Recurrent in-stent restenosis (R-ISR) refers to the re-occlusion of a successfully treated in-stent restenosis. Much of the present understanding of this condition stems from studies on in-stent restenosis, as literature on R-ISR is sparse. Compounded by multiple previous struts, narrower luminal diameters and worse patient profiles, R-ISR is a clinical challenge that demands urgent attention.
View Article and Find Full Text PDFBackground: The "weekend effect" is a purported phenomenon whereby patients admitted for time-sensitive medical and surgical conditions on a weekend suffer worse outcomes than those admitted on a weekday. There are limited data on the weekend effect for nonelective coronary artery bypass grafting (CABG).
Methods: We studied outcomes for weekend vs weekday operations for all adult patients in the 2013 to 2014 National Inpatient Sample (NIS) undergoing nonelective CABG.
Article Synopsis
- - Patients undergoing transcatheter aortic valve implantation (TAVI) typically have coronary angiography to assess coronary artery disease (CAD), but the benefits of adding percutaneous coronary intervention (PCI) during TAVI are unclear.
- - A comprehensive literature review of 11 studies involving 5,580 patients showed no significant differences in critical outcomes such as 30-day mortality, stroke, myocardial infarction, and kidney injury between those receiving TAVI with or without PCI.
- - The study concluded that PCI does not provide additional clinical benefits for TAVI patients with severe aortic stenosis and CAD, indicating a need for more randomized studies to clarify the role of myocardial revascularization in this context.
Endothelial precursor cells (EPCs) cultured from adult bone marrow (BM) have been shown to mediate neovasculogenesis in murine models of vascular injury. We sought to directly compare umbilical cord blood (UCB)- and BM-derived EPC surface phenotypes and in vivo functional capacity. UCB and BM EPCs derived from mononuclear cells (MNC) were phenotyped by surface staining for expression of stromal (Stro-1, CXCR4, CD105, and CD73), endothelial (CD31, CD146, and vascular endothelial [VE]-cadherin), stem cell (CD34 and CD133), and monocyte (CD14) surface markers and analyzed by flow cytometry.
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