Publications by authors named "David Ojok"
Article Synopsis
- The study investigates rotavirus infections in fully vaccinated children in Zambia, highlighting the emergence of genetically altered viruses that can evade immunity from existing vaccines.
- Researchers conducted whole genome sequencing on diarrheal stool samples and identified several RVA strains, including mono and multiple reassortant strains, which exhibited differences in antigenic epitope compared to the common vaccine strain, Rotarix.
- Results suggest that these genetic variations may help the virus escape neutralizing antibodies, indicating a need for improved vaccination strategies and the development of more effective universal rotavirus vaccines.
Background: Bacteria of the order Enterobacterales are common pathogens causing bloodstream infections in sub-Saharan Africa and are frequently resistant to third-generation cephalosporin antibiotics. Although third-generation cephalosporin resistance is believed to lead to adverse outcomes, this relationship is difficult to quantify and has rarely been studied in this region. We aimed to measure the effects associated with resistance to third-generation cephalosporins in hospitalised patients with Enterobacterales bloodstream infection in Africa.
View Article and Find Full Text PDFBloodstream infections caused by Enterobacterales show high frequency of antimicrobial resistance (AMR) in many Low- and Middle-Income Countries. We aimed to describe the variation in circumstances for management of such resistant infections in a group of African public-sector hospitals participating in a major research study. We gathered data from eight hospitals across sub-Saharan Africa to describe hospital services, infection prevention and antibiotic stewardship activities, using two WHO-generated tools.
View Article and Find Full Text PDFBackground: We evaluated the field performance of a rapid point-of-care (POC) test for hepatitis B surface antigen (HBsAg) that could support decentralization and scale-up of hepatitis B virus (HBV) diagnosis in Africa.
Objective: To determine the field performance of the Determine HBsAg POC test for diagnosis of HBV co-infection among HIV patients in Zambia.
Study Design: Between 2013-2014, we screened HIV-infected adults for HBsAg at two urban clinics in Zambia.