Publications by authors named "David O Tovar-Anaya"
Article Synopsis
- Computational modeling (CM) is a valuable method for analyzing complex systems like biopolymers in biomedical engineering, predicting experiment results, and speeding up scientific progress.
- Key areas of CM in biopolymer research include Computer-aided design (CAD/CAM) for creating detailed 3D models, finite element analysis for studying mechanical properties, and molecular dynamics (MD) simulations for understanding molecular behavior.
- The integration of in silico and in vitro experiments in CM enhances research efficiency and reduces costs, marking a growing trend in biomedical engineering fields.
Correction to: Stabilized Human Cystatin C, Variant L47C/G69C, is a Better Reporter than the Wild-type Inhibitor for Characterizing the Thermodynamics of Binding to Cysteine Proteases.
Protein J
October 2019
The original publication of this article contained a number of grammatical errors. Unfortunately, an incorrect version of the file that did not include some final language editing was inadvertently published online. The original article has been corrected.
View Article and Find Full Text PDFStabilized Human Cystatin C Variant L47C/G69C Is a Better Reporter Than the Wild-Type Inhibitor for Characterizing the Thermodynamics of Binding to Cysteine Proteases.
Protein J
October 2019
Human cystatin C (HCC) binds and inhibits all types of cysteine proteases from the papain family, including cathepsins (a group of enzymes that participate in a variety of physiological processes), which are some of its natural targets. The affinities of diverse proteases for HCC, expressed as equilibrium binding constants (K), range from 10 to 10 M. Isothermal titration calorimetry (ITC) is one of the most useful techniques to characterize the thermodynamics of molecular associations, making it possible to dissect the binding free energy into its enthalpic and entropic components.
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