Publications by authors named "David Nwobodo"
Ethnomedicinal plants are thought to have better prospects of harboring endophytes that produce natural products with pharmacological activities. This study aimed to investigate the antiplasmodial and anticancer properties of secondary metabolites of endophytic fungi from three medicinal plants. The endophytic fungi included Lasiodiplodia theobromae isolated from Cola acuminata, Curvularia lunata Bv4 isolated from Bambusa vulgaris, and Curvularia lunata Eg7 isolated from Elaeis guineensis.
View Article and Find Full Text PDFPrevalence of plasmid-mediated quinolone resistance genes and biofilm formation in different species of quinolone-resistant clinical Shigella isolates: a cross-sectional study.
Eur J Med Res
August 2024
Article Synopsis
- The study aimed to investigate plasmid-mediated quinolone resistance (PMQR) genes and biofilm formation in Shigella isolates that are resistant to quinolones, using clinical samples from children under 10 years old.
- Researchers collected stool samples from 150 patients, identifying 95 Shigella isolates primarily as S. sonnei and S. flexneri, with a notable percentage showing multidrug resistance.
- The presence of PMQR genes was significant, especially qnrS and qnrA, and biofilm formation was also assessed, indicating a complex challenge for treatment options in these resistant strains.
Article Synopsis
- * While many existing Nrf2 activators are electrophilic, PTZs are non-electrophilic and may pose fewer risks for unwanted side effects, making them attractive for further study.
- * This review offers a comprehensive look at how PTZs function as antioxidants and their possible therapeutic benefits for diseases linked to oxidative stress, aiming to inspire new research ideas in this area.
This study investigated the bacteriological quality of ready-to-eat (RTE) African salads in Enugu metropolis, Enugu, Nigeria. A total of 10 samples of African salad were purchased from 10 different vendors in Enugu metropolis. The samples were purchased from Agbani Road, Ogbete, Mayor, Uwani, Kenyatta, Achara Layout, Obiagu and Timber.
View Article and Find Full Text PDFObjectives: This study evaluated the prevalence, antibiogram and molecular features of CA-MRSA in Awka, Nigeria.
Methods: Confirmation of MRSA was done by testing resistance to oxacillin (1µg), cloxacillin (5µg) and cefoxitin 30µg) on sterile Mueller Hinton agar supplemented with 4% sodium chloride. The MRSA strains were subjected to antimicrobial susceptibility testing using Kirby-Bauer disc diffusion method.