Effects of Recreational Camping on the Environmental Values of National Parks in Sri Lanka.

Camping is a popular activity in the contemporary nature-based tourism domain and rapidly gaining momentum as a key recreational activity in Sri Lanka's national parks (NPs). Recreational uses such as camping in natural areas can induce significant and often localised resource impacts that can affect soil, vegetation, wildlife and water, with the severity of such impacts varying according to the intensity of use. Hence, monitoring of the biophysical conditions of campsites has become an important component in the reserve management agenda in many places, especially in developed countries.

Scoping Recreational Disturbance of Shorebirds to Inform the Agenda for Research and Management in Tropical Asia.

In addition to scoping the impacts of the four most reported sources of recreational disturbance on shorebirds, this study also advances the concept of Tropical Asia (TA) to collectively describe tourist destinations in the ecologically and geopolitically diverse part of the planet that incorporates the tourism megaregion of South and Southeast Asia. At a time of growing global concern about the rapid decline of shorebird populations, many governments in TA are embracing and capitalising on the exponential growth in demand for coastal recreation and tourism across the region. This political response is partly driven by efforts to deliver economic development, aligned to the United Nations Sustainable Development Goals, in order to secure the livelihoods of people living in less developed coastal areas.

Data from a survey to determine visitor attitudes and knowledge about the provisioning of wild dolphins at a marine tourism destination.

In the Austral summer of 2014-2015 we surveyed visitors at the popular marine tourism destination of Koombana Bay, Bunbury, Western Australia to investigate resident and visitor attitudes towards the provisioning of the wild dolphins and their knowledge about the legal, social and environmental repercussions arising from the unregulated provisioning of the dolphins. We report the data collected in our survey along with our preliminary statistical analyses and the survey instrument we utilized to collect the data.

Fibroblasts Enhance Migration of Human Lung Cancer Cells in a Paper-Based Coculture System.

A multilayered paper-based platform is used to investigate the interactions between human lung tumor cells and fibroblasts that are isolated from primary patient tumor samples.

Understanding the conflicting values associated with motorized recreation in protected areas.

The International Union for the Conservation of Nature World Parks Congress in 2014 reported that the quality of management of protected areas is crucial in halting the loss of the world's biodiversity and meeting global environmental challenges. However, increasingly high-impact activities, including motorized recreation are occurring in protected areas such as national parks, creating an ongoing clash of values and further compromising protected area management. This paper discusses the values of protected areas in the context of increasingly high-impact motorized usage, the impact of divergent values placed on green spaces such as national parks, and perceptions about these spaces.

Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma.

Background: Constitutive MET signaling promotes invasiveness in most primary and recurrent GBM. However, deployment of available MET-targeting agents is confounded by lack of effective biomarkers for selecting suitable patients for treatment. Because endogenous HGF overexpression often causes autocrine MET activation, and also indicates sensitivity to MET inhibitors, we investigated whether it drives the expression of distinct genes which could serve as a signature indicating vulnerability to MET-targeted therapy in GBM.

Synthesis and Quasi-Static Compressive Properties of Mg-AZ91D-Al₂O₃ Syntactic Foams.

Magnesium alloys have considerably lower density than the aluminum alloy matrices that are typically used in syntactic foams, allowing for greater specific energy absorption. Despite the potential advantages, few studies have reported the properties of magnesium alloy matrix syntactic foams. In this work, Al₂O₃ hollow particles of three different size ranges, 0.

Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.

The Rho kinases (ROCK1 and ROCK2) are highly homologous serine/threonine kinases that act on substrates associated with cellular motility, morphology, and contraction and are of therapeutic interest in diseases associated with cellular migration and contraction, such as hypertension, glaucoma, and erectile dysfunction. Beginning with compound 4, an inhibitor of ROCK1 identified through high-throughput screening, systematic exploration of SAR, and application of structure-based design, led to potent and selective ROCK inhibitors. Compound 37 represents significant improvements in inhibition potency, kinase selectivity, and CYP inhibition and possesses pharmacokinetics suitable for in vivo experimentation.

A paper-based invasion assay: assessing chemotaxis of cancer cells in gradients of oxygen.

This work describes a 3D, paper-based assay that can isolate sub-populations of cells based on their invasiveness (i.e., distance migrated in a hydrogel) in a gradient of concentration of oxygen (O2).

Impact of technical assistants for venepuncture and intravenous cannulation on overall emergency department performance.

Objective: The objective of the article was to determine the effect of a technical assistant for venepuncture and i.v. cannulation on triage performance and patient length of stay in an ED.

Comparing hiking, mountain biking and horse riding impacts on vegetation and soils in Australia and the United States of America.

Hiking, horse riding and mountain biking are popular in protected areas in Australia and the United States of America. To help inform the often contentious deliberations about use of protected areas for these three types of activities, we review recreation ecology research in both countries. Many impacts on vegetation, soils and trails are similar for the three activities, although there can be differences in severity.

Reproducible measurement of macular light flash recovery time using a novel device can indicate the presence and worsening of macular diseases.

Purpose: To determine the safety, sensitivity, and specificity of a novel flash photorecovery timing instrument with response verification in differentiating normal from abnormal maculae, and in detecting worsening macular disease.

Methods: Right and left eye photorecovery times were determined at baseline and after 5 min using a xenon arc, flash filtered for infrared, ultraviolet, and visible short wavelengths, delivered through an aperture in a hand-held tube. A push-button actuated timer and flash and stopped timer when lighted numbers became visible post-flash.

A randomized, prospective, placebo-controlled clinical trial of a novel zinc-monocysteine compound in age-related macular degeneration.

Purpose: To test the hypothesis that daily use of zinc-monocysteine (ZMC) supplement will be well tolerated and result in improved macular function in persons with dry age-related macular degeneration (AMD).

Methods: Eligible, consenting subjects were randomized to either ZMC 25 mg or placebo twice daily for 6 months. Both ZMC and placebo groups enrolled 40 participants, with best corrected visual acuity 20/25 to 20/70, macular drusen, and pigment changes.

Molecular dynamics simulations of mass transfer resistance in grain boundaries of twinned zeolite membranes.

The net mass transfer resistance for gas molecules permeating through zeolite membranes includes contributions from intracrystalline diffusion and contributions from interfacial effects. These interfacial effects can arise either from gas-zeolite interfaces or from interfaces that exist within zeolite crystals due to grain boundaries. We present the first atomically detailed simulations that examine interfacial mass transfer resistance due to internal grain boundaries in zeolites that are relevant for membrane applications.

Influences of interfacial resistances on gas transport through carbon nanotube membranes.

Carbon nanotubes have significant promise as gas separation membranes. Gas permeation through nanopores involves mass transfer resistances from molecules entering and leaving pores (so-called surface resistances) and diffusion within the pores. We use molecular simulations to give the first estimates of surface resistances for gas transport through nanotubes.

A novel zinc compound (zinc monocysteine) enhances the antioxidant capacity of human retinal pigment epithelial cells.

Purpose: The aim of this study was to document the effect of a novel zinc amino acid combination on the concentrations of important antioxidants in cultured human retinal pigment epithelial (hRPE) cells.

Methods: Primary confluent hRPE cells were treated with 30 microM of zinc acetate, zinc chloride, zinc cysteine, and zinc sulfate. The antioxidants catalase, glutathione, glutathione peroxidase, and metallothionein were measured.

Predictive assessment of surface resistances in zeolite membranes using atomically detailed models.

The diffusive transport of molecules through nanoporous membranes is determined by both intracrystalline diffusion and mass transport resistances associated with entering and leaving the membrane material. We compare two methods for assessing the relative importance of these resistances based on atomically detailed descriptions of the membrane material. For extremely thin membranes, net transport can be assessed using dual control volume grand canonical molecular dynamics (DCV-GCMD).

An electrophoretic method to deliver topical drugs to the eye.

It is possible that many patients avoid complete ophthalmic exams because pupil dilation is slow, reversal sluggish, and vision blurred. Others experience incomplete dilation during exams or prior to surgery when good dilation is essential to successful outcome. Iontophoresis, the application of low-level electrical current to promote traversal of desired molecules across a boundary, has been used for many years and has recently become common in transdermal drug delivery.

Expression of metallothionein isoforms in human chorioretinal complex.

Purpose: To determine the relative expression of metallothionein isoforms and their differential induction by oxidative stress in cultured RPE cells and to localize the isoforms in the human chorioretinal complex.

Methods: Total RNA was isolated from cultured human retinal pigment epithelial cells using TRI-Reagent. An "anchor-oligo-dT primer" was used for the synthesis of cDNA, reverse transcribed using avian reverse transcriptase and subsequently subjected to PCR analysis using oligonucleotides specific for metallothionein (MT) I, MT II, and MT III.