Publications by authors named "David Nemeth"
Article Synopsis
- * A review of nine randomized controlled trials (RCTs) involving 529 patients indicated no significant differences in mortality, anastomosis leakage, respiratory issues, or vomiting, though results regarding gastric emptying time (GET) presented mixed findings.
- * The study suggests that pyloric drainage is not essential in these operations, but emphasizes the need for further research, especially in European contexts, to draw more definitive conclusions.
RTCONF55-16K is a new, reactive conformational data set based on cost-efficient methods to assess different conformational analysis protocols. Our reference calculations underpinned the accuracy of the CENSO (Grimme et al. , 2021, 125, 4039) procedure and resulted in alternative recipes with different cost-accuracy compromises.
View Article and Find Full Text PDFObjective: This study aimed to investigate the prognostic role of concomitant histological fetal inflammatory response with chorioamnionitis on neonatal outcomes through a systematic review and meta-analysis of existing literature.
Data Sources: The primary search was conducted on October 17, 2021, and it was updated on May 26, 2023, across 4 separate databases (MEDLINE, the Cochrane Central Register of Controlled Trials, Embase, and Scopus) without using any filters.
Study Eligibility Criteria: Observational studies reporting obstetrical and neonatal outcomes of infant-mother dyads with histological chorioamnionitis and histological fetal inflammatory response vs infant-mother dyads with histological chorioamnionitis alone were eligible.
Article Synopsis
- * A total of 175 patients were analyzed, revealing that 54.29% experienced dyspeptic symptoms, which were significantly associated with seropositivity for autoimmune diseases, particularly celiac disease.
- * The findings suggest that autoimmune disease markers may contribute to dyspeptic symptoms, indicating a need for more research into the cost-effectiveness of screening for autoantibodies in dyspeptic patients.
Background: Previous meta-analyses, with many limitations, have described the beneficial nature of minimal invasive procedures.
Aim: To compare all modalities of esophagectomies to each other from the results of randomized controlled trials (RCTs) in a network meta-analysis (NMA).
Methods: We conducted a systematic search of the MEDLINE, EMBASE, (https://www.
A rare case of delayed jejunal perforation is reported, with a time window of approximately five hours. The diagnosis is challenging: there are no proper protocols, planned early physical examination checkups are advised. The forensic medical aspects of the occasional therapeutical delays are remarkable.
View Article and Find Full Text PDFBackground: Decades of debate surround the use of intraoperative cholangiography (IOC) during cholecystectomy. To the present day, the role of IOC is controversial as regards decreasing the rate of bile duct injury (BDI). We aimed to review and analyse the available literature on the benefits of IOC during cholecystectomy.
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- Chronic gastritis (CG) often has an unknown cause but is linked to serious conditions like gastric cancer; the study aimed to investigate potential underlying factors and the role of autoimmune disorders in patients with CG.
- The study analyzed 175 patients with CG and found that 55% had autoantibodies, with a significant association between these autoantibodies and precancerous stomach lesions such as intestinal metaplasia and atrophy.
- Specific antibodies, especially those related to systemic lupus erythematosus, were linked to higher risks of these lesions, highlighting the need for further investigation into autoimmune conditions in CG cases.
Background: Frailty, a "syndrome of loss of reserves," is a decade old concept. Initially it was used mainly in geriatrics but lately its use has been extended into other specialties including surgery. Our main objective was to examine the association between frailty and mortality, between frailty and length of hospital stay (LOS) and frailty and readmission within 30 days in the emergency surgical population.
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- Noninvasive ventilation (NIV) shows promise in reducing mortality and intubation rates in adults with pneumonia-associated respiratory failure compared to not using NIV, although overall hospital mortality differences were not statistically significant.
- In intensive care settings, NIV significantly lowered mortality rates, demonstrating its effectiveness, especially among patients with overlapping conditions like COPD.
- The results suggest that NIV should be considered in treatment guidelines for pneumonia-related respiratory failure due to its substantial benefits in critical care outcomes.
Maternal overnutrition elevates offspring's blood pressure-A systematic review and meta-analysis.
Paediatr Perinat Epidemiol
March 2022
Article Synopsis
- Maternal overnutrition during pregnancy is linked to higher blood pressure (BP) in offspring, with a positive correlation found between maternal prepregnancy body mass index (ppBMI) and both systolic and diastolic BP in children.
- In the analysis of data from 17 studies with over 140,000 mother-offspring pairs, every 5 kg/m² increase in maternal ppBMI was associated with an increase of 1.9 mmHg in systolic and 0.5 mmHg in diastolic BP of offspring.
- While gestational weight gain (GWG) initially showed a relationship with offspring systolic BP, the correlation diminished when adjusting for the child's BMI,
The prevalence of hyponatremia is highly variable among patients with lung cancer. However, its prevalence and prognostic significance in subgroups of patients with lung cancer have not yet been evaluated in a meta-analysis. We have registered our meta-analysis and review protocol to the PROSPERO International Prospective Register of Systematic Reviews, with the following registration number: CRD42020167013.
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- The rising incidence of acute pancreatitis (AP) has led to increased medical costs and a concerning 30% mortality rate in severe cases.
- A study involving 2461 patients revealed that hypoalbuminemia (low albumin levels) is common in AP, affecting 19% on admission and 35.7% during hospitalization.
- Severe hypoalbuminemia significantly increases the risk of complications and mortality, with a clear dose-dependent relationship to severity and hospital stay.
Hepatitis C virus (HCV)-infected patients treated with direct-acting antivirals (DAAs) are still at risk of developing hepatocellular carcinoma (HCC) after sustained virologic response (SVR). This study aimed to investigate the role of diabetes mellitus (DM) as a potential predictive risk factor in developing HCC in HCV-infected patients after DAA treatment. This study was registered on PROSPERO under registration number CRD42021230457.
View Article and Find Full Text PDFObjectives: Immune regulation seems to be altered in cystic fibrosis (CF), thus potentially predisposing patients to developing autoimmune diseases (AID). In this meta-analysis, we aimed to evaluate the prevalence of celiac disease (CeD) among CF patients as by far the most commonly reported autoimmune disease in this population and, secondly, to review the observations on other, less frequently studied autoimmune diseases.
Methods: We conducted a systematic literature search for studies that discussed AIDs among CF patients.
Acute pancreatitis (AP) is a life-threatening disease. We aimed to explore the prognostic relevance of renal function based on estimated glomerular filtration rate (eGFR). A prospective registry of AP patients was established by the Hungarian Pancreatic Study Group.
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- Multiple tissues in the gastrointestinal tract, including periodontal structures, are essential for food delivery, but they are difficult to regenerate once damaged, leading to reliance on traditional treatments for periodontal disease like scaling and root planning.
- Probiotics have been suggested as a new way to improve oral health by potentially reducing harmful bacteria through their anti-inflammatory properties, although research results on their effectiveness have been mixed.
- A meta-analysis was conducted analyzing nine studies, which showed that probiotics significantly decreased certain bacterial counts after 4 weeks, but did not have a lasting impact or a significant effect on overall bacterial counts in higher-risk areas of the mouth.
infection is a major determinant of morbidity and mortality in cystic fibrosis (CF). Maintaining optimal lung function in CF patients carrying remains a challenge. Our study aims to investigate the efficacy of antipseudomonal inhaled antibiotics in CF patients with chronic infection.
View Article and Find Full Text PDFObjective: The goal of treatment in ulcerative colitis (UC) is to induce and maintain remission. The addition of granulocyte and monocyte apheresis (GMA) to conventional therapy may be a promising therapeutic alternative. In this meta-analysis, we aimed to assess the efficacy and safety profile of GMA as an adjunctive therapy.
View Article and Find Full Text PDFThe hunt for useful sepsis biomarkers is ongoing. Macrophage migration inhibitory factor (MIF) was implicated as a biomarker in sepsis, but its diagnostic and prognostic value has remained unclear in human studies. Here, we aimed at clarifying the value of MIF as a sepsis biomarker with the meta-analysis of clinical trials.
View Article and Find Full Text PDFAbnormal cholesterol level is a major risk factor in the development of atherosclerosis, which is a fundamental derangement in cardiovascular diseases. Any efforts should be undertaken to lower blood cholesterol levels. Among dietary interventions, capsaicinoid supplementation is also considered as a novel cholesterol-lowering approach, but human studies concluded contradictory results about its effectiveness.
View Article and Find Full Text PDFDespite routine supplementation, vitamin D insufficiency is often seen in cystic fibrosis (CF) patients on account of pancreatic insufficiency. Vitamin D is a crucial component of bone health and affects nearly all cells of the immune system. However, clinical benefits or harms associated with supplementation are poorly documented.
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- - The study conducted a systematic review and meta-analysis to assess how liver function tests and liver diseases at the time of admission impact the severity and outcomes of COVID-19, analyzing data from 50 studies registered on PROSPERO.
- - Key findings indicated that factors like acute liver failure, chronic liver disease, platelet counts, and liver enzyme levels (ALT, AST) were significant predictors for ICU admission, high severity cases, and in-hospital mortality rates in COVID-19 patients.
- - Overall, the research established that having pre-existing liver conditions or experiencing acute liver injury during COVID-19 significantly affects prognosis and can help in predicting patient outcomes.
Despite the growing knowledge of the clinicopathological features of COVID-19, the correlation between early changes in the laboratory parameters and the clinical outcomes of patients is not entirely understood. In this study, we aimed to assess the prognostic value of early laboratory parameters in COVID-19. We conducted a systematic review and meta-analysis based on the available literature in five databases.
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