Pathogenesis of metaphyseal radiolucent changes following ischemic necrosis of the capital femoral epiphysis in immature pigs. A preliminary report.

Background: Although metaphyseal radiolucent changes are often seen in patients with Legg-Calvé-Perthes disease, the pathogenesis of these changes remains controversial. The purpose of the present study was to determine the prevalence and histopathological characteristics of these metaphyseal radiolucent changes in a piglet model of ischemic necrosis of the capital femoral epiphysis.

Methods: Ischemic necrosis of the right femoral head was produced in fifty piglets by surgically placing a ligature tightly around the femoral neck.

Anxiety and depression in hospitalized patients in resistant organism isolation.

Background: Previous studies have reported an increase in psychiatric symptoms in seriously ill patients who were placed in resistant organism isolation. We conducted this study to assess whether there is an increase in symptoms of anxiety and depression in patients who are not critically ill and are placed in isolation.

Methods: Patients hospitalized with methicillin-resistant Staphylococcus aureus or vancomycin-resistant Enterococcus species infections were evaluated with the Hamilton Anxiety Rating Scale and the Hamilton Depression Rating Scale at baseline and again during hospitalization.