Publications by authors named "David N Oskardmay"
Background: Choline, a gut microbiome metabolite, is associated with cardiovascular risk and other chronic illnesses. The aim was to develop a high-throughput nuclear magnetic resonance (NMR)-based assay to measure choline on the Vantera® Clinical Analyzer.
Methods: A non-negative deconvolution algorithm was developed to quantify choline.
The extended lipid panel assay: a clinically-deployed high-throughput nuclear magnetic resonance method for the simultaneous measurement of lipids and Apolipoprotein B.
Lipids Health Dis
December 2020
Background: Standard lipid panel assays employing chemical/enzymatic methods measure total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C), from which are calculated estimates of low-density lipoprotein cholesterol (LDL-C). These lipid measures are used universally to guide management of atherosclerotic cardiovascular disease risk. Apolipoprotein B (apoB) is generally acknowledged to be superior to LDL-C for lipid-lowering therapeutic decision-making, but apoB immunoassays are performed relatively infrequently due to the added analytic cost.
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- - A new nuclear magnetic resonance (NMR) spectroscopy test was developed to measure ketone bodies (β-hydroxybutyrate, acetoacetate, and acetone), which is important for monitoring certain health conditions and dietary plans.
- - The test showed high precision and reliability, with strong correlations to traditional measurement methods, and was validated using data from a study on insulin resistance involving nearly 1200 participants.
- - Results indicated that ketone body levels were higher in individuals with type 2 diabetes compared to non-diabetics, and these levels were linked to free fatty acids while inversely related to triglycerides and insulin resistance.