Publications by authors named "David Mirer"
Background: Antigen-specific memory B cells play a key role in the induction of desensitization and remission to food allergens in oral immunotherapy and in the development of natural tolerance (NT). Here, we characterized milk allergen Bos d 9-specific B cells in oral allergen-specific immunotherapy (OIT) and in children spontaneously outgrowing cow's milk allergy (CMA) due to NT.
Methods: Samples from children with CMA who received oral OIT (before, during, and after), children who naturally outgrew CMA (NT), and healthy individuals were received from Stanford biobank.
Background: Although avian coronavirus infectious bronchitis virus (IBV) and SARS-CoV-2 belong to different genera of the Coronaviridae family, exposure to IBV may result in the development of cross-reactive antibodies to SARS-CoV-2 due to homologous epitopes. We aimed to investigate whether antibody responses to IBV cross-react with SARS-CoV-2 in poultry farm personnel who are occupationally exposed to aerosolized IBV vaccines.
Methods: We analyzed sera from poultry farm personnel, COVID-19 patients, and pre-pandemic controls.
Article Synopsis
- Rhinoviruses are the leading cause of respiratory infections and can trigger asthma attacks, but the cellular immune response, particularly in B cells, is not fully understood.
- The study analyzed B cells from infected healthy individuals and asthma patients using RNA-sequencing to observe their response to rhinovirus infection, finding that B cells in both groups had unique antiviral gene expressions.
- Key findings include B cells differentiating into plasmablasts after exposure to rhinovirus, an absence of interferon expression in response to the virus, and notable dysregulation of antiviral genes in asthma patients, which could affect responses to other respiratory viruses.
Loss of regulatory capacity in Treg cells following rhinovirus infection.
J Allergy Clin Immunol
October 2021
Background: Respiratory infections with rhinoviruses (RV) are strongly associated with development and exacerbations of asthma, and they pose an additional health risk for subjects with allergy.
Objective: How RV infections and chronic allergic diseases are linked and what role RV plays in the breaking of tolerance in regulatory T (Treg) cells is unknown. Therefore, this study aims to investigate the effects of RV on Treg cells.
Background: Asthma patients present with distinct immunological profiles, with a predominance of type 2 endotype. The aim of this study was to investigate the impact of high-altitude treatment on the clinical and immunological response in asthma.
Methods: Twenty-six hospitalized asthma patients (nine eosinophilic allergic; EA, nine noneosinophilic allergic; NEA and eight noneosinophilic nonallergic; NN) and nine healthy controls in high altitude for 21 days were enrolled in the study.