Publications by authors named "David Michael Bradburn"
Article Synopsis
- - DNA methylation is crucial for gene regulation and cell function, with changes noted during development, aging, and various diseases, alongside potential influence from diet.
- - A systematic review of 60 dietary intervention studies in adults revealed mixed methods and a focus on folic acid, with evidence indicating it may lead to increased DNA methylation in colorectal tissue.
- - Overall, the study found limited evidence for dietary influences on DNA methylation beyond folic acid, and variability in measurement methods poses challenges for comparing results across different studies.
Bowel cancer risk is strongly influenced by lifestyle factors including diet and physical activity. Several studies have investigated the effects of adherence to the World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) cancer prevention recommendations on outcomes such as all-cause and cancer-specific mortality, but the relationships with molecular mechanisms that underlie the effects on bowel cancer risk are unknown. This study aimed to investigate the relationships between adherence to the WCRF/AICR cancer prevention recommendations and wingless/integrated (WNT)-pathway-related markers of bowel cancer risk, including the expression of WNT pathway genes and regulatory microRNA (miRNA), secreted frizzled-related protein 1 (SFRP1) methylation and colonic crypt proliferative state in colorectal mucosal biopsies.
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