Publications by authors named "David Mayes"
Background And Objectives: Satralizumab, an interleukin 6 receptor inhibitor, reduced the risk of protocol-defined relapse (PDR) vs placebo in 2 independent, double-blind studies in patients with neuromyelitis optica spectrum disorder (NMOSD). We assessed the long-term efficacy of satralizumab in patients with aquaporin-4-immunoglobulin G (IgG)-seropositive (AQP4-IgG+) NMOSD.
Methods: Following the double-blind periods of SAkuraSky (satralizumab + baseline immunosuppressive treatment [IST]) and SAkuraStar (satralizumab monotherapy), patients could enter the open-label extension (OLE, satralizumab 120 mg Q4W ± IST).
Hewletts Creek, in Wilmington, North Carolina, drains a large suburban watershed and as such is affected by high fecal bacteria loads and periodic algal blooms from nutrient loading. During 2007, a 3.1-ha wetland was constructed to treat stormwater runoff from a 238-ha watershed within the Hewletts Creek drainage.
View Article and Find Full Text PDFVisible and short-wavelength near-infrared (SW-NIR) spectroscopy (600-1100 nm) was used to detect bruises in intact, whole Pacific pink salmon (Oncorhynchus gorbuscha). The measurements were performed noninvasively through the skin and scales in the diffuse reflectance mode. Digital images of bruised and nonbruised regions of fish were captured after the fish samples were filleted.
View Article and Find Full Text PDFArticle Synopsis
- Data was collected from three wet detention ponds in Wilmington, NC, over 29 months, with varying drainage areas affecting water quality outcomes.
- One urban pond showed significant reductions in pollutants like nitrogen and phosphorus, attributed to its design and diverse aquatic plant life, while another urban pond reduced turbidity but not nutrient concentrations due to suburban runoff disrupting the process.
- The golf course pond had increased nutrient levels in its outflow, likely due to fertilizer use, but still performed better than other golf courses due to passing through a wooded wetland after discharge; emphasizing the need for optimal wet pond design to enhance pollutant removal.