Publications by authors named "David Mate Csiki"
Zinc is the second most abundant trace element in the human body, stored mainly in the bones. Zinc is required for bone growth and homeostasis and is also a crucial cofactor for numerous proteins that play key roles in maintaining microstructural integrity and bone remodeling. Bone marrow-derived mesenchymal stem cells (BMSCs) are multipotent progenitors found in the bone marrow stroma and can differentiate along multiple lineage pathways.
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- - Vascular calcification in chronic kidney disease (CKD) patients increases cardiovascular risks, and the drug Daprodustat (DPD) accelerates this calcification while treating anemia associated with CKD by activating the HIF-1 pathway.
- - DPD treatment enhances markers indicating hypoxia, ER stress, and osteogenic differentiation in both CKD mice and human vascular cells, leading to increased calcification in aorta and kidneys.
- - The study reveals that DPD induces ER stress via the ATF4 pathway, with the potential to mitigate its pro-calcification effects by targeting ATF4 in therapies.
Patients with advanced chronic kidney disease (CKD) have elevated circulating calcium × phosphate product levels and exhibit soft tissue calcification. Besides the cardiovascular system, calcification is commonly observed in the cornea in CKD patients on hemodialysis. Cardiovascular calcification is a cell-mediated, highly regulated process, and we hypothesized that a similar regulatory mechanism is implicated in corneal calcification with the involvement of corneal epithelial cells (CECs).
View Article and Find Full Text PDFCataract, a leading cause of blindness, is characterised by lens opacification. Type 2 diabetes is associated with a two- to fivefold higher prevalence of cataracts. The risk of cataract formation increases with the duration of diabetes and the severity of hyperglycaemia.
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- Valve calcification (VC) is common in chronic kidney disease (CKD) and involves valve interstitial cells (VICs) undergoing an osteogenic transition, with the hypoxia inducible factor (HIF) pathway playing a crucial but unclear role in this process.
- Research in CKD mice showed that high phosphate levels increased markers of osteogenic transition and HIF activation, leading to enhanced calcification in VICs, particularly under hypoxic conditions.
- The findings suggest that HIF activation contributes to VC via mechanisms involving reactive oxygen species and cell death, indicating that targeting the HIF pathway could be a potential therapeutic approach for treating aortic VC in CKD patients.
Vascular calcification (VC) is associated with a number of cardiovascular diseases, as well as chronic kidney disease. The role of smooth muscle cells (SMC) has already been widely explored in VC, as has the role of intracellular Ca in regulating SMC function. Increased intracellular calcium concentration ([Ca]) in vascular SMC has been proposed to stimulate VC.
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- Chronic kidney disease (CKD) is often linked with anemia, and Daprodustat (DPD), a drug that enhances red blood cell production, activates the HIF-1 pathway, which may lead to vascular calcification.
- Research showed that DPD not only stabilized HIF-1α and HIF-2α but also escalated calcification in human vascular cells and mice with CKD caused by high phosphate.
- Though DPD helped correct anemia in CKD mice, it also increased aortic calcification, suggesting that further long-term studies are necessary to assess the potential risks of HIF-1 pathway activation in CKD patients.
Calcific aortic valve stenosis (CAVS) is a heart disease characterized by the progressive fibro-calcific remodeling of the aortic valves, an actively regulated process with the involvement of the reactive oxygen species-mediated differentiation of valvular interstitial cells (VICs) into osteoblast-like cells. Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the expression of a variety of antioxidant genes, and plays a protective role in valve calcification. Heme oxygenase-1 (HO-1), an Nrf2-target gene, is upregulated in human calcified aortic valves.
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