Hepatotoxicity From Disease-Modifying Anti-rheumatic Drugs (DMARDs) and Association With Metabolic Syndrome in Rheumatoid Arthritis.

Objectives: Hepatotoxicity is a frequent reason why disease-modifying anti-rheumatic drugs (DMARDs) are stopped or changed. We hypothesize that features of metabolic syndrome (such as obesity, dyslipidemia, and diabetes) are risk factors for hepatotoxicity leading to DMARD change in rheumatoid arthritis (RA).

Methods:  We conducted a retrospective chart review of 361 patients with RA.

Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd.

The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both (IC = 9.