Prognostic value and therapeutic implications of nodal involvement in head and neck mucosal melanoma.

Background: The prognostic significance of nodal involvement is not well established in head and neck mucosal melanoma (HNMM).

Methods: A retrospective, monocentric study was performed on 96 patients with HNMM treated between 2000 and 2017.

Results: At diagnosis, seventeen patients (17.

Pathogenesis of chronic rhinosinusitis with nasal polyps: role of IL-6 in airway epithelial cell dysfunction.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by an alteration in airway epithelial cell functions including barrier function, wound repair mechanisms, mucociliary clearance. The mechanisms leading to epithelial cell dysfunction in nasal polyps (NPs) remain poorly understood. Our hypothesis was that among the inflammatory cytokines involved in NPs, IL-6 could alter epithelial repair mechanisms and mucociliary clearance.

Risk-based stratification in head and neck mucosal melanoma.

Background: Head and neck mucosal melanoma (HNMM) is a rare and aggressive disease with a high metastatic potential. Two staging systems are currently available: one specific to HNMM (mmTNM) and one specific to primary tumour sites (sccTNM). Our main objective was to assess the prognostic value of both of these classifications in order to allow accurate risk-based classification.

Investigating hyperventilation syndrome in patients suffering from empty nose syndrome.

Objectives/hypothesis: Patients with empty nose syndrome (ENS) following turbinate surgery often complain about breathing difficulties. We set out to determine if dyspnea in patients with ENS was associated with hyperventilation syndrome (HVS). We hypothesized that lower airway symptoms in ENS could be explained by HVS.