Publications by authors named "David Malnoe"
Article Synopsis
- Graft-versus-host disease (GVHd) poses a challenge after allogeneic hematopoietic stem cell transplantation (HSCT), with ciclosporin used for prevention but showing complex variations in metabolism due to factors like inflammation.
- A study involving 71 adult HSCT patients assessed the relationship between inflammation levels (measured by C-reactive protein) and ciclosporin metabolism, finding that severe inflammation led to decreased metabolism but did not affect blood levels thanks to dose adjustments.
- The study concluded that inflammation significantly impacts ciclosporin pharmacokinetics, emphasizing the need for careful therapeutic monitoring and potential personalized dosage strategies in HSCT patients.
(1) Background: Oral targeted anticancer drugs are victims of presystemic pharmacokinetic drug−drug interactions (DDI). Identification of the nature of these DDIs, i.e.
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